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Tbio
SF3A3
Splicing factor 3A subunit 3

Protein Summary
Description
Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373019
  • ENSP00000362110
  • ENSG00000183431

Symbol
  • SAP61
  • PRP9
  • PRPF9
  • SAP61
  • SF3a60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor binding site profile
0.97
kinase perturbation
0.96
interacting protein
0.92
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.98   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.98   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (316)
CCDC97
Tdark
Novelty:  2.36351796
p_int:  0.999976154
p_ni:  0.000023846
Score:  0.534
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999958
p_ni:  0.000042
Score:  0.984
Data Source:  BioPlex,STRINGDB
SNRPB2
Tbio
Novelty:  0.17219587
p_int:  0.999732966
p_ni:  0.000267034
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.99963585
p_ni:  0.00036415
Score:  0.994
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.998568148
p_ni:  0.001431852
Data Source:  BioPlex
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.998220721
p_ni:  0.001779279
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.995758995
p_ni:  0.004241
p_wrong:  4e-9
Score:  0.979
Data Source:  BioPlex,STRINGDB
RBM17
Tchem
Novelty:  0.04840999
p_int:  0.995429797
p_ni:  0.004570203
Score:  0.978
Data Source:  BioPlex,STRINGDB
QPRT
Tbio
Family:  Enzyme
Novelty:  0.00781554
p_int:  0.986142837
p_ni:  0.013857163
Data Source:  BioPlex
ZRSR2
Tbio
Novelty:  0.03449891
p_int:  0.985944001
p_ni:  0.014055999
Score:  0.645
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of RNA (R-HSA-8953854)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
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Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
2
2
3
90.8
4
2
4
76.3
2
2
0
1.1
63.1
body height
1
1
1
57.8
heel bone mineral density
3
1
3
56.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
3
90.8
4
76.3
0
1.1
63.1
body height
1
57.8
heel bone mineral density
3
56.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
splicing factor 3a subunit 3
VGNC:1541
745795
Macaque
splicing factor 3a subunit 3
715267
Mouse
MGI:1922312
75062
Rat
RGD:1308726
313583
Dog
splicing factor 3a subunit 3
475326
Species
Name
OMA
EggNOG
Inparanoid
Chimp
splicing factor 3a subunit 3
Macaque
splicing factor 3a subunit 3
Mouse
Rat
Dog
splicing factor 3a subunit 3
Publication Statistics
PubMed Score 29.98
PubMed score by year
PubTator Score 6.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title