Tbio SF3A1 Splicing factor 3A subunit 1

Protein Summary

Description

Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. [provided by RefSeq, Aug 2014]

Uniprot Accession IDs

• Q15459
• E9PAW1

Gene Name

• SF3A1

Ensembl ID

• ENST00000215793
• ENSP00000215793
• ENSG00000099995

Symbol

• SAP114
• PRP21
• PRPF21
• SAP114
• SF3A120

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
hub protein	0.96
virus perturbation	0.94
kinase perturbation	0.88
transcription factor perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Splicing Factor 3a Subunit 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Splicing Factor 3a Subunit 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.2   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 241   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.2   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (346)

Explore Interacting Targets

1 – 10 of 346

• See Interactions on String-DB

CCDC97

Tdark

Novelty:  2.36351796

p_int:  0.999886996

p_ni:  0.000113004

Score:  0.803

Data Source:  BioPlex,STRINGDB

SNRPB2

Tbio

Novelty:  0.17219587

p_int:  0.999847832

p_ni:  0.000152168

Score:  0.989

Data Source:  BioPlex,STRINGDB

SNRPE

Tbio

Novelty:  0.02033423

p_int:  0.999600952

p_ni:  0.000399048

Score:  0.981

Data Source:  BioPlex,STRINGDB

SNRPA1

Tbio

Novelty:  0.01232044

p_int:  0.999516811

p_ni:  0.000483189

Score:  0.999

Data Source:  BioPlex,STRINGDB

PHF5A

Tbio

Family:  Epigenetic

Novelty:  0.02989472

p_int:  0.998517322

p_ni:  0.001482678

Score:  0.992

Data Source:  BioPlex,STRINGDB

RBM17

Tbio

Novelty:  0.04840999

p_int:  0.994219596

p_ni:  0.005780404

Score:  0.983

Data Source:  BioPlex,STRINGDB

SNRPGP15

Tdark

p_int:  0.991199681

p_ni:  0.008800319

Data Source:  BioPlex

HSPA8

Tchem

Novelty:  0.00081014

p_int:  0.989827049

p_ni:  0.010172951

Score:  0.915

Data Source:  BioPlex,STRINGDB

SNRPN

Tbio

Novelty:  0.002157

p_int:  0.985966304

p_ni:  0.014033696

Score:  0.982

Data Source:  BioPlex,STRINGDB

QPRT

Tbio

Family:  Enzyme

Novelty:  0.00781554

p_int:  0.970794841

p_ni:  0.029205159

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (4)

KEGG (1)

WikiPathways (1)

Metabolism of RNA (R-HSA-8953854)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	mRNA Splicing	188 targets	R-HSA-72172
Reactome	mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
mRNA Splicing	188 targets	R-HSA-72172
mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (1)

Components (7)

Processes (3)

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1 – 1 of 1

GO Term	Evidence	Assigned by
RNA binding	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (18)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 18

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6	2	6		91.3
platelet crit	EFO_0007985	2	2	2		82.5
heel bone mineral density	EFO_0009270	2	2	4		70.1
platelet count	EFO_0004309	1	1	1		57.3
reticulocyte count	EFO_0007986	1	1	1		56

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 18

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6		91.3
platelet crit	EFO_0007985	2		82.5
heel bone mineral density	EFO_0009270	4		70.1
platelet count	EFO_0004309	1		57.3
reticulocyte count	EFO_0007986	1		56

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Complete proteome
Isopeptide bond
mRNA processing
mRNA splicing
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
calcium measurement
coronary artery disease
eosinophil percentage of leukocytes
heel bone mineral density
hematocrit
platelet count
platelet crit
pulse pressure measurement

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	splicing factor 3a subunit 1	VGNC:6011	458750
Macaque	splicing factor 3a subunit 1		715552
Mouse	splicing factor 3a, subunit 1	MGI:1914715	67465
Rat	splicing factor 3a, subunit 1	RGD:1311477	305479
Dog	splicing factor 3a subunit 1	VGNC:46067	477538

Species	Name	OMA	EggNOG	Inparanoid
Chimp	splicing factor 3a subunit 1
Macaque	splicing factor 3a subunit 1
Mouse	splicing factor 3a, subunit 1
Rat	splicing factor 3a, subunit 1
Dog	splicing factor 3a subunit 1

Publication Statistics

PubMed Score 26.20

PubMed score by year

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PubTator Score 11.12

PubTator score by year

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Related Publications

Text Mined References (53)

GeneRif Annotations (8)

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PMID	Year	Title