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Tbio
SF3A1
Splicing factor 3A subunit 1

Protein Summary
Description
Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. [provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215793
  • ENSP00000215793
  • ENSG00000099995

Symbol
  • SAP114
  • PRP21
  • PRPF21
  • SAP114
  • SF3A120
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
0.96
virus perturbation
0.94
kinase perturbation
0.88
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.2   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.2   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (346)
CCDC97
Tdark
Novelty:  2.36351796
p_int:  0.999886996
p_ni:  0.000113004
Score:  0.803
Data Source:  BioPlex,STRINGDB
SNRPB2
Tbio
Novelty:  0.17219587
p_int:  0.999847832
p_ni:  0.000152168
Score:  0.989
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999600952
p_ni:  0.000399048
Score:  0.981
Data Source:  BioPlex,STRINGDB
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.999516811
p_ni:  0.000483189
Score:  0.999
Data Source:  BioPlex,STRINGDB
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.998517322
p_ni:  0.001482678
Score:  0.992
Data Source:  BioPlex,STRINGDB
RBM17
Tbio
Novelty:  0.04840999
p_int:  0.994219596
p_ni:  0.005780404
Score:  0.983
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.991199681
p_ni:  0.008800319
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.989827049
p_ni:  0.010172951
Score:  0.915
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.985966304
p_ni:  0.014033696
Score:  0.982
Data Source:  BioPlex,STRINGDB
QPRT
Tbio
Family:  Enzyme
Novelty:  0.00781554
p_int:  0.970794841
p_ni:  0.029205159
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
91.3
platelet crit
2
2
2
82.5
heel bone mineral density
2
2
4
70.1
platelet count
1
1
1
57.3
reticulocyte count
1
1
1
56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
91.3
platelet crit
2
82.5
heel bone mineral density
4
70.1
platelet count
1
57.3
reticulocyte count
1
56
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
splicing factor 3a subunit 1
VGNC:6011
458750
Macaque
splicing factor 3a subunit 1
715552
Mouse
MGI:1914715
67465
Rat
RGD:1311477
305479
Dog
splicing factor 3a subunit 1
VGNC:46067
477538
Species
Name
OMA
EggNOG
Inparanoid
Chimp
splicing factor 3a subunit 1
Macaque
splicing factor 3a subunit 1
Mouse
Rat
Dog
splicing factor 3a subunit 1
Publication Statistics
PubMed Score 26.20
PubMed score by year
PubTator Score 11.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title