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Tbio
SF1
Splicing factor 1

Protein Summary
Description
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227503
  • ENSP00000227503
  • ENSG00000168066
  • ENST00000334944
  • ENSP00000334414
  • ENST00000377387
  • ENSP00000366604
  • ENST00000377390
  • ENSP00000366607
  • ENST00000377394
  • ENSP00000366611
  • ENST00000433274
  • ENSP00000396793

Symbol
  • ZFM1
  • ZNF162
  • BBP
  • MBBP
  • ZFM1
  • ZNF162
  • D11S636
  • ZCCHC25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
interacting protein
0.94
transcription factor
0.93
transcription factor binding site profile
0.89
hub protein
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.92   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 372   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.92   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 372   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (293)
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
p_int:  0.985341136
p_ni:  0.014658864
Score:  0.16
Data Source:  BioPlex,STRINGDB
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.956987696
p_ni:  0.043012304
Data Source:  BioPlex
BCHE
Tclin
Family:  Enzyme
Novelty:  0.00031267
p_int:  0.956744625
p_ni:  0.043255375
Score:  0.197
Data Source:  BioPlex,STRINGDB
CAPN13
Tbio
Novelty:  0.27206398
p_int:  0.954282459
p_ni:  0.045717541
Score:  0.189
Data Source:  BioPlex,STRINGDB
HSPBP1
Tbio
Novelty:  0.01176285
p_int:  0.953223059
p_ni:  0.046776941
Data Source:  BioPlex
HAO2
Tchem
Family:  Enzyme
Novelty:  0.03029536
p_int:  0.922271518
p_ni:  0.077728481
Score:  0.179
Data Source:  BioPlex,STRINGDB
SFPQ
Tbio
Novelty:  0.01207637
p_int:  0.850175377
p_ni:  0.149824623
Score:  0.721
Data Source:  BioPlex,STRINGDB
U2AF2
Tbio
Novelty:  0.00590935
Score:  0.999
Data Source:  STRINGDB
PRPF40A
Tbio
Novelty:  0.00898047
Score:  0.994
Data Source:  STRINGDB
SF3B1
Tbio
Novelty:  0.0128965
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
18
18
99.5
uric acid measurement
4
3
3
13.8
98.9
renal system measurement
1
1
1
94.8
3
2
0
1.4
72.2
body mass index
2
2
2
60.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
18
99.5
uric acid measurement
3
13.8
98.9
renal system measurement
1
94.8
0
1.4
72.2
body mass index
2
60.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
splicing factor 1
VGNC:1007
466656
Mouse
MGI:1095403
22668
Rat
RGD:620645
117855
Dog
splicing factor 1
VGNC:46066
476031
Horse
splicing factor 1
VGNC:22885
100050420
Species
Name
OMA
EggNOG
Inparanoid
Chimp
splicing factor 1
Mouse
Rat
Dog
splicing factor 1
Horse
splicing factor 1
Publication Statistics
PubMed Score 95.92
PubMed score by year
PubTator Score 436.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title