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Tbio
SETX
Probable helicase senataxin

Protein Summary
Description
Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In asso ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
interacting protein
0.98
biological process
0.96
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.83


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.44   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 304   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.44   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 304   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (194)
PIAS4
Tbio
Family:  TF
Novelty:  0.01388547
p_int:  0.999089217
p_ni:  0.000910783
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.997677054
p_ni:  0.002322946
Data Source:  BioPlex
VPS28
Tbio
Novelty:  0.02927315
p_int:  0.996676063
p_ni:  0.003323936
p_wrong:  1e-9
Data Source:  BioPlex
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.996202618
p_ni:  0.003797382
Data Source:  BioPlex
VWA5A
Tbio
Novelty:  0.0802354
p_int:  0.993119565
p_ni:  0.006880435
Data Source:  BioPlex
IFT27
Tbio
Family:  Enzyme
Novelty:  0.05592902
p_int:  0.959229717
p_ni:  0.040770271
p_wrong:  1.2e-8
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.954226226
p_ni:  0.045773773
Data Source:  BioPlex
COMTD1
Tdark
Family:  Enzyme
Novelty:  0.245971
p_int:  0.94921152
p_ni:  0.050788475
p_wrong:  4e-9
Data Source:  BioPlex
NME2P1
Tdark
Family:  Kinase
p_int:  0.934048552
p_ni:  0.065951448
Data Source:  BioPlex
CIB2
Tbio
Novelty:  0.03578691
p_int:  0.920131074
p_ni:  0.079864297
p_wrong:  0.000004629
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Interactome of polycomb repressive complex 2 (PRC2)
WikiPathways
Circadian rhythm related genes
Name
Explore in Pharos
Explore in Source
Interactome of polycomb repressive complex 2 (PRC2)
Circadian rhythm related genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
UniProtKB
Inferred by Curator (IC)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
irritability measurement
1
1
0
7
54.4
hip circumference
1
1
1
53.7
mood instability measurement
1
1
1
42.3
1
1
0
2.9
24.5
BMI-adjusted hip circumference
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
irritability measurement
0
7
54.4
hip circumference
1
53.7
mood instability measurement
1
42.3
0
2.9
24.5
BMI-adjusted hip circumference
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
senataxin
VGNC:4861
464815
Macaque
senataxin
715065
Mouse
MGI:2443480
269254
Rat
RGD:1565575
362096
Dog
senataxin
VGNC:46062
480691
Species
Name
OMA
EggNOG
Inparanoid
Chimp
senataxin
Macaque
senataxin
Mouse
Rat
Dog
senataxin
Publication Statistics
PubMed Score 248.44
PubMed score by year
PubTator Score 101.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title