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Tbio
SETD5
SET domain-containing protein 5

Protein Summary
Description
Probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Acts as a regulator of histone acetylation during gene transcription. This function of this gene has yet to be determined but based on sequence similarity to other SET domain proteins it may function as a histone methyltransferase. Mutations in this gene have been associated with an autosomal dominant form of intellectual disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302463
  • ENSP00000302028
  • ENSG00000168137
  • ENST00000402198
  • ENSP00000385852
  • ENST00000406341
  • ENSP00000383939

Symbol
  • KIAA1757
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
transcription factor
0.89
cell type or tissue
0.71
cell line
0.69
histone modification site profile
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.16   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.16   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
p_int:  0.996545674
p_ni:  0.003452585
p_wrong:  0.000001742
Score:  0.202
Data Source:  BioPlex,STRINGDB
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.984657124
p_ni:  0.003534218
p_wrong:  0.011808657
Score:  0.186
Data Source:  BioPlex,STRINGDB
PRMT2
Tbio
Family:  Epigenetic
Novelty:  0.04121581
p_int:  0.956187079
p_ni:  0.002442863
p_wrong:  0.041370057
Score:  0.195
Data Source:  BioPlex,STRINGDB
PRR20E
Tdark
p_int:  0.944518545
p_ni:  0.024127427
p_wrong:  0.031354028
Score:  0.187
Data Source:  BioPlex,STRINGDB
KMT2A
Tchem
Family:  Epigenetic
Novelty:  0.00192554
Score:  0.859
Data Source:  STRINGDB
THUMPD3
Tdark
Novelty:  0.23224828
Score:  0.813
Data Source:  STRINGDB
SETD4
Tbio
Family:  Epigenetic
Novelty:  0.1994878
Score:  0.773
Data Source:  STRINGDB
RNF219
Tdark
Novelty:  0.26163921
Score:  0.75
Data Source:  STRINGDB
SMYD3
Tchem
Family:  Epigenetic
Novelty:  0.01040802
Score:  0.715
Data Source:  STRINGDB
SETD2
Tchem
Family:  Epigenetic
Novelty:  0.00178899
Score:  0.714
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
51.4
2
1
2
50.6
C-reactive protein measurement
1
1
1
50.6
waist-hip ratio
1
1
1
38.2
body height
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
51.4
2
50.6
C-reactive protein measurement
1
50.6
waist-hip ratio
1
38.2
body height
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SET domain containing 5
704174
Mouse
MGI:1920145
72895
Rat
RGD:1310433
297514
Dog
SET domain containing 5
100856259
Horse
SET domain containing 5
VGNC:52436
100052472
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SET domain containing 5
Mouse
Rat
Dog
SET domain containing 5
Horse
SET domain containing 5
Publication Statistics
PubMed Score 30.16
PubMed score by year
PubTator Score 10.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title