SETD5
SET domain-containing protein 5
Protein Summary
Probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Acts as a regulator of histone acetylation during gene transcription. This function of this gene has yet to be determined but based on sequence similarity to other SET domain proteins it may function as a histone methyltransferase. Mutations in this gene have been associated with an autosomal dominant form of intellectual disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
- ENST00000302463
- ENSP00000302028
- ENSG00000168137
- ENST00000402198
- ENSP00000385852
- ENST00000406341
- ENSP00000383939
- KIAA1757
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.94 | ||
transcription factor | 0.89 | ||
cell type or tissue | 0.71 | ||
cell line | 0.69 | ||
histone modification site profile | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.23 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 79 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 35.23 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 79 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0