You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SETD1B
Histone-lysine N-methyltransferase SETD1B

Protein Summary
Description
Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro. SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000542440
  • ENSP00000442924
  • ENSG00000139718
  • ENST00000604567
  • ENSP00000474253
  • ENST00000619791
  • ENSP00000481531

Symbol
  • KIAA1076
  • KMT2G
  • SET1B
  • KMT2G
  • Set1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
microRNA
0.8
molecular function
0.76
protein domain
0.73
cell type or tissue
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.52   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.52   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (254)
CXXC1
Tbio
Family:  Epigenetic
Novelty:  0.01019251
p_int:  0.999999973
p_ni:  2.6e-8
p_wrong:  1e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999999742
p_ni:  2.41e-7
p_wrong:  1.7e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999934592
p_ni:  0.000065406
p_wrong:  1e-9
Score:  0.174
Data Source:  BioPlex,STRINGDB
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.999682472
p_ni:  0.000317525
p_wrong:  2e-9
Data Source:  BioPlex
PRMT2
Tbio
Family:  Epigenetic
Novelty:  0.04121581
p_int:  0.994155304
p_ni:  0.005523273
p_wrong:  0.000321423
Score:  0.642
Data Source:  BioPlex,STRINGDB
RBBP5
Tbio
Novelty:  0.02221059
Score:  0.999
Data Source:  STRINGDB
ASH2L
Tbio
Family:  Enzyme
Novelty:  0.01586766
Score:  0.998
Data Source:  STRINGDB
WDR82
Tbio
Novelty:  0.04679153
Score:  0.997
Data Source:  STRINGDB
DPY30
Tbio
Novelty:  0.03098629
Score:  0.997
Data Source:  STRINGDB
KMT2E
Tbio
Family:  Epigenetic
Novelty:  0.01893047
Score:  0.99
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
PKMTs methylate histone lysines
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
11
6
15
99.6
platelet crit
2
2
4
95.8
platelet count
3
2
2
3.9
95.4
reticulocyte measurement
3
2
3
86.4
mean reticulocyte volume
1
1
1
83.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
15
99.6
platelet crit
4
95.8
platelet count
2
3.9
95.4
reticulocyte measurement
3
86.4
mean reticulocyte volume
1
83.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SET domain containing 1B
VGNC:5580
473295
Mouse
MGI:2652820
208043
Rat
Dog
SET domain containing 1B
VGNC:46053
486257
Horse
SET domain containing 1B
VGNC:50972
100146430
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SET domain containing 1B
Mouse
Rat
Dog
SET domain containing 1B
Horse
SET domain containing 1B
Publication Statistics
PubMed Score 28.52
PubMed score by year
PubTator Score 12.50
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title