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Tbio
SETBP1
SET-binding protein

Protein Summary
Description
This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282030
  • ENSP00000282030
  • ENSG00000152217
  • ENST00000426838
  • ENSP00000390687
  • ENST00000649279
  • ENSP00000497406

Symbol
  • KIAA0437
  • SEB
  • MRD29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.95
phenotype
0.77
trait
0.75
disease
0.69
PubMedID
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.77   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.77   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
TST
Tchem
Family:  Enzyme
Novelty:  0.00214991
Score:  0.86
Data Source:  STRINGDB
FUT2
Tbio
Family:  Enzyme
Novelty:  0.0009286
Score:  0.84
Data Source:  STRINGDB
EPHX2
Tchem
Family:  Enzyme
Novelty:  0.00430741
Score:  0.84
Data Source:  STRINGDB
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
Score:  0.782
Data Source:  STRINGDB
ASXL1
Tbio
Family:  Epigenetic
Novelty:  0.00342965
Score:  0.766
Data Source:  STRINGDB
CCDC6
Tbio
Novelty:  0.00702098
Score:  0.762
Data Source:  STRINGDB
BPTF
Tchem
Family:  Epigenetic
Novelty:  0.00826037
Score:  0.761
Data Source:  STRINGDB
SELENOO
Tdark
Novelty:  0.02959704
Score:  0.758
Data Source:  STRINGDB
TRIP12
Tbio
Family:  Enzyme
Novelty:  0.03433452
Score:  0.719
Data Source:  STRINGDB
SELENOK
Tbio
Novelty:  0.02182816
Score:  0.718
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
3
3
76.9
electrocardiography
1
1
7
68.8
reticulocyte measurement
2
1
2
56.6
BMI-adjusted hip circumference
1
3
3
56.3
reticulocyte count
2
1
2
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
3
76.9
electrocardiography
7
68.8
reticulocyte measurement
2
56.6
BMI-adjusted hip circumference
3
56.3
reticulocyte count
2
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SET binding protein 1 [Source:HGNC Symbol;Acc:HGNC:15573]
Mouse
MGI:1933199
240427
Rat
RGD:1306229
291423
Dog
SET binding protein 1
VGNC:46051
490472
Horse
SET binding protein 1
VGNC:22873
100053128
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SET binding protein 1 [Source:HGNC Symbol;Acc:HGNC:15573]
Mouse
Rat
Dog
SET binding protein 1
Horse
SET binding protein 1
Publication Statistics
PubMed Score 358.77
PubMed score by year
PubTator Score 285.72
PubTator score by year
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Related Publications
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PMID
Year
Title