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Tbio
SET
Protein SET

Protein Summary
Description
Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. The protein encoded by this gene inhibits acetylation of nucleosomes, especial ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322030
  • ENSP00000318012
  • ENSG00000119335
  • ENST00000372686
  • ENSP00000361771
  • ENST00000372692
  • ENSP00000361777
  • ENST00000409104
  • ENSP00000387321

Symbol
  • 2PP2A
  • IGAAD
  • MRD58
  • TAF-I
  • I2PP2A
  • IPP2A2
  • PHAPII
  • TAF-IBETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
kinase perturbation
1
disease perturbation
0.99
hub protein
0.99
interacting protein
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.34   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 347   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.34   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 347   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
REPIN1
Tbio
Family:  TF
Novelty:  0.01152362
p_int:  1
Score:  0.206
Data Source:  BioPlex,STRINGDB
ZDBF2
Tdark
Novelty:  0.19205154
p_int:  0.998439921
p_ni:  0.001560078
p_wrong:  1e-9
Score:  0.239
Data Source:  BioPlex,STRINGDB
RPL36AL
Tbio
Novelty:  0.09336423
p_int:  0.99445528
p_ni:  0.00554472
Score:  0.345
Data Source:  BioPlex,STRINGDB
TRIM23
Tbio
Family:  Enzyme
Novelty:  0.12751063
p_int:  0.994138686
p_ni:  0.005861314
Score:  0.345
Data Source:  BioPlex,STRINGDB
HSPA14
Tbio
Novelty:  0.01714625
p_int:  0.974093329
p_ni:  0.025906662
p_wrong:  9e-9
Score:  0.279
Data Source:  BioPlex,STRINGDB
TSPYL2
Tbio
Novelty:  0.03720016
p_int:  0.95468546
p_ni:  0.045314539
Score:  0.201
Data Source:  BioPlex,STRINGDB
ANP32A
Tbio
Novelty:  0.00567095
Score:  0.99
Data Source:  STRINGDB
NME1
Tbio
Family:  Kinase
Novelty:  0.00103216
Score:  0.986
Data Source:  STRINGDB
APEX1
Tchem
Family:  Enzyme
Novelty:  0.00037532
Score:  0.982
Data Source:  STRINGDB
GZMA
Tbio
Family:  Enzyme
Novelty:  0.00322362
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Condensation of Prophase Chromosomes
Reactome
HuR (ELAVL1) binds and stabilizes mRNA
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Condensation of Prophase Chromosomes
HuR (ELAVL1) binds and stabilizes mRNA
M Phase
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
91.9
platelet crit
2
2
2
89.4
sex hormone-binding globulin measurement
6
1
6
83.3
platelet count
1
1
1
71.6
myeloid white cell count
1
1
1
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
91.9
platelet crit
2
89.4
sex hormone-binding globulin measurement
6
83.3
platelet count
1
71.6
myeloid white cell count
1
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SET nuclear proto-oncogene
VGNC:4860
100613143
Macaque
SET nuclear proto-oncogene
693242
Mouse
MGI:1860267
56086
Rat
RGD:1307467
307947
Rat
RGD:1305921
296619
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SET nuclear proto-oncogene
Macaque
SET nuclear proto-oncogene
Mouse
Rat
Rat
Publication Statistics
PubMed Score 92.34
PubMed score by year
PubTator Score 49.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title