Tbio SERPING1 Plasma protease C1 inhibitor

Protein Summary

Description

Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P05155
• A6NMU0
• A8KAI9
• B2R6L5
• B4E1F0
• B4E1H2
• Q16304
• Q547W3
• Q59EI5
• Q7Z455
• Q96FE0
• Q9UC49
• Q9UCF9
• C1 Inh

Gene Name

• SERPING1

Ensembl ID

• ENST00000278407
• ENSP00000278407
• ENSG00000149131
• ENST00000378323
• ENSP00000367574
• ENST00000378324
• ENSP00000367575

Symbol

• C1IN
• C1NH
• C1IN
• C1NH
• HAE1
• HAE2
• C1INH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
virus perturbation	0.88
small molecule perturbation	0.84
biological process	0.82
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Plasma Protease C1 Inhibitor

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Plasma Protease C1 Inhibitor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1788.83   (req: < 5)

Gene RIFs: 153   (req: <= 3)

Antibodies: 514   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1788.83   (req: >= 5)

Gene RIFs: 153   (req: > 3)

Antibodies: 514   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0