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Tbio
SERPINF2
Alpha-2-antiplasmin

Protein Summary
Description
Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324015
  • ENSP00000321853
  • ENSG00000167711
  • ENST00000382061
  • ENSP00000371493
  • ENST00000450523
  • ENSP00000403877
  • ENST00000618883
  • ENSP00000479005
  • ENSG00000276838
  • ENST00000622842
  • ENSP00000481874

Symbol
  • AAP
  • PLI
  • AAP
  • API
  • PLI
  • A2AP
  • ALPHA-2-PI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
gene perturbation
0.84
cellular component
0.65
disease
0.62
biological term
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1679.57   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 496   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1679.57   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 496   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (158)
RNASEH1
Tchem
Family:  Enzyme
Novelty:  0.01838314
p_int:  0.999995035
p_ni:  0.000004965
Data Source:  BioPlex
DAPP1
Tbio
Novelty:  0.05145215
p_int:  0.999983638
p_ni:  0.000016354
p_wrong:  8e-9
Data Source:  BioPlex
PLAT
Tclin
Family:  Enzyme
Novelty:  0.00017503
p_int:  0.999942222
p_ni:  0.000057778
Score:  0.984
Data Source:  BioPlex,STRINGDB
POMGNT2
Tbio
Family:  Enzyme
Novelty:  0.15109569
p_int:  0.99975874
p_ni:  0.00024126
Data Source:  BioPlex
HIBADH
Tbio
Family:  Enzyme
Novelty:  0.03861647
p_int:  0.998567909
p_ni:  0.00143209
Data Source:  BioPlex
EMB
Tbio
Novelty:  0.00135577
p_int:  0.988870429
p_ni:  0.009530179
p_wrong:  0.001599392
Data Source:  BioPlex
PLG
Tclin
Family:  Enzyme
Novelty:  0.00004806
Score:  0.995
Data Source:  Reactome,STRINGDB
A2M
Tbio
Novelty:  0.00070446
Score:  0.98
Data Source:  STRINGDB
FGA
Tbio
Novelty:  0.00107227
Score:  0.975
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.962
Data Source:  STRINGDB
Pathways (20)
Dissolution of Fibrin Clot (R-HSA-75205)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Dissolution of Fibrin Clot
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Dissolution of Fibrin Clot
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
3
5
6
97.6
serum albumin measurement
3
5
6
97.6
sex hormone-binding globulin measurement
6
3
8
96.6
sex hormone-binding globulin measurement
6
3
8
96.6
calcium measurement
1
3
3
93.4
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
6
97.6
serum albumin measurement
6
97.6
sex hormone-binding globulin measurement
8
96.6
sex hormone-binding globulin measurement
8
96.6
calcium measurement
3
93.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family F member 2
VGNC:51732
454412
Macaque
serpin family F member 2
100427699
Mouse
MGI:107173
18816
Rat
RGD:1306692
287527
Dog
serpin family F member 2
VGNC:46040
611266
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family F member 2
Macaque
serpin family F member 2
Mouse
Rat
Dog
serpin family F member 2
Publication Statistics
PubMed Score 1679.57
PubMed score by year
PubTator Score 1319.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title