SERPINF2
Alpha-2-antiplasmin
Protein Summary
Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
- ENST00000324015
- ENSP00000321853
- ENSG00000167711
- ENST00000382061
- ENSP00000371493
- ENST00000450523
- ENSP00000403877
- ENST00000618883
- ENSP00000479005
- ENSG00000276838
- ENST00000622842
- ENSP00000481874
- AAP
- PLI
- AAP
- API
- PLI
- A2AP
- ALPHA-2-PI
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.99 | ||
gene perturbation | 0.84 | ||
cellular component | 0.65 | ||
disease | 0.62 | ||
biological term | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1596.6 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 496 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1596.6 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 496 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0