You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SERPINF1
Pigment epithelium-derived factor

Protein Summary
Description
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254722
  • ENSP00000254722
  • ENSG00000132386

Symbol
  • PEDF
  • OI6
  • OI12
  • PEDF
  • EPC-1
  • PIG35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
disease perturbation
0.96
small molecule perturbation
0.94
gene perturbation
0.83
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.22   (req: < 5)
Gene RIFs: 247   (req: <= 3)
Antibodies: 574   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.22   (req: >= 5)
Gene RIFs: 247   (req: > 3)
Antibodies: 574   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
L3MBTL2
Tbio
Family:  Epigenetic
Novelty:  0.11193867
p_int:  0.999999328
p_ni:  6.72e-7
Score:  0.163
Data Source:  BioPlex,STRINGDB
MMP19
Tbio
Family:  Enzyme
Novelty:  0.01407961
p_int:  0.997270474
p_ni:  0.002729526
Score:  0.156
Data Source:  BioPlex,STRINGDB
ADAM18
Tdark
Family:  Enzyme
Novelty:  0.22622379
p_int:  0.996841634
p_ni:  0.003156973
p_wrong:  0.000001394
Data Source:  BioPlex
KLHL8
Tdark
Novelty:  0.4838314
p_int:  0.962686326
p_ni:  0.037133173
p_wrong:  0.000180501
Score:  0.237
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.920037199
p_ni:  0.079962801
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.844783113
p_ni:  0.155216887
Score:  0.17
Data Source:  BioPlex,STRINGDB
LRP6
Tbio
Novelty:  0.00305615
Score:  0.901
Data Source:  STRINGDB
LRP5
Tbio
Novelty:  0.00089807
Score:  0.884
Data Source:  STRINGDB
VEGFA
Tclin
Novelty:  0.0000378
Score:  0.819
Data Source:  STRINGDB
IFITM5
Tbio
Novelty:  0.01404042
Score:  0.788
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
3
5
6
97.6
sex hormone-binding globulin measurement
6
3
8
96.6
calcium measurement
1
3
3
93.4
alkaline phosphatase measurement
2
2
2
12
92.3
testosterone measurement
4
4
5
89.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
6
97.6
sex hormone-binding globulin measurement
8
96.6
calcium measurement
3
93.4
alkaline phosphatase measurement
2
12
92.3
testosterone measurement
5
89.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family F member 1
VGNC:10074
468137
Mouse
MGI:108080
20317
Rat
RGD:631369
287526
Dog
serpin family F member 1
VGNC:46039
611276
Horse
serpin family F member 1
VGNC:22859
100072415
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family F member 1
Mouse
Rat
Dog
serpin family F member 1
Horse
serpin family F member 1
Publication Statistics
PubMed Score 196.22
PubMed score by year
PubTator Score 543.98
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title