SERPINF1
Pigment epithelium-derived factor
Protein Summary
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016]
- ENST00000254722
- ENSP00000254722
- ENSG00000132386
- PEDF
- OI6
- OI12
- PEDF
- EPC-1
- PIG35
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.97 | ||
disease perturbation | 0.96 | ||
small molecule perturbation | 0.94 | ||
gene perturbation | 0.83 | ||
transcription factor perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 196.22 (req: < 5)
Gene RIFs: 247 (req: <= 3)
Antibodies: 574 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 196.22 (req: >= 5)
Gene RIFs: 247 (req: > 3)
Antibodies: 574 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (66)
L3MBTL2
Family: Epigenetic
Novelty: 0.11193867
p_int: 0.999999328
p_ni: 6.72e-7
Score: 0.163
Data Source: BioPlex,STRINGDB
MMP19
Family: Enzyme
Novelty: 0.01407961
p_int: 0.997270474
p_ni: 0.002729526
Score: 0.156
Data Source: BioPlex,STRINGDB
ADAM18
Family: Enzyme
Novelty: 0.22622379
p_int: 0.996841634
p_ni: 0.003156973
p_wrong: 0.000001394
Data Source: BioPlex
KLHL8
Novelty: 0.4838314
p_int: 0.962686326
p_ni: 0.037133173
p_wrong: 0.000180501
Score: 0.237
Data Source: BioPlex,STRINGDB
HSPA5
Novelty: 0.00043424
p_int: 0.844783113
p_ni: 0.155216887
Score: 0.17
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (38)
KEGG (1)
WikiPathways (37)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Wnt signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Wnt signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (1)
Components (8)
Processes (22)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum albumin measurement | 3 | 5 | 6 | 97.6 | |||||
sex hormone-binding globulin measurement | 6 | 3 | 8 | 96.6 | |||||
calcium measurement | 1 | 3 | 3 | 93.4 | |||||
alkaline phosphatase measurement | 2 | 2 | 2 | 12 | 92.3 | ||||
testosterone measurement | 4 | 4 | 5 | 89.7 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum albumin measurement | 6 | 97.6 | |||||
sex hormone-binding globulin measurement | 8 | 96.6 | |||||
calcium measurement | 3 | 93.4 | |||||
alkaline phosphatase measurement | 2 | 12 | 92.3 | ||||
testosterone measurement | 5 | 89.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | serpin family F member 1 | VGNC:10074 | 468137 | |||||
Mouse | MGI:108080 | 20317 | ||||||
Rat | RGD:631369 | 287526 | ||||||
Dog | serpin family F member 1 | VGNC:46039 | 611276 | |||||
Horse | serpin family F member 1 | VGNC:22859 | 100072415 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | serpin family F member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | serpin family F member 1 | |||||
Horse | serpin family F member 1 | |||||
Publication Statistics
PubMed Score 196.22
PubMed score by year
PubTator Score 543.98
PubTator score by year
Related Publications
Text Mined References (290)
GeneRif Annotations (247)
Items per page:
0 of 0
PMID | Year | Title |
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