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Tchem
SERPINE1
Plasminogen activator inhibitor 1

Protein Summary
Description
Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin format ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223095
  • ENSP00000223095
  • ENSG00000106366

Symbol
  • PAI1
  • PLANH1
  • PAI
  • PAI1
  • PAI-1
  • PLANH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
0.99
gene perturbation
0.96
PubMedID
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6635.07   (req: < 5)
Gene RIFs: 963   (req: <= 3)
Antibodies: 1326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6635.07   (req: >= 5)
Gene RIFs: 963   (req: > 3)
Antibodies: 1326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 72
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (318)
PLAT
Tclin
Family:  Enzyme
Novelty:  0.00017503
Score:  0.999
Data Source:  Reactome,STRINGDB
PLAU
Tchem
Family:  Enzyme
Novelty:  0.0005322
Score:  0.999
Data Source:  Reactome,STRINGDB
PLG
Tclin
Family:  Enzyme
Novelty:  0.00004806
Score:  0.998
Data Source:  STRINGDB
VTN
Tbio
Family:  TF
Novelty:  0.00046861
Score:  0.998
Data Source:  Reactome,STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
Score:  0.99
Data Source:  Reactome,STRINGDB
VEGFA
Tclin
Novelty:  0.0000378
Score:  0.982
Data Source:  STRINGDB
TGFB1
Tbio
Novelty:  0.0001299
Score:  0.979
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.979
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.979
Data Source:  STRINGDB
VWF
Tclin
Novelty:  0.00009007
Score:  0.978
Data Source:  STRINGDB
Pathways (112)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Reactome
Dissolution of Fibrin Clot
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Dissolution of Fibrin Clot
ECM proteoglycans
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
81.5
body mass index
1
1
1
44.2
plasminogen activator inhibitor 1 measurement
1
1
1
38.7
apolipoprotein A 1 measurement
1
1
1
38.2
body height
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
81.5
body mass index
1
44.2
plasminogen activator inhibitor 1 measurement
1
38.7
apolipoprotein A 1 measurement
1
38.2
body height
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family E member 1
VGNC:10053
472467
Macaque
serpin family E member 1
713883
Mouse
MGI:97608
18787
Rat
RGD:3249
24617
Dog
serpin family E member 1
VGNC:46036
403476
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family E member 1
Macaque
serpin family E member 1
Mouse
Rat
Dog
serpin family E member 1
Publication Statistics
PubMed Score 6635.07
PubMed score by year
PubTator Score 4911.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title