Tclin SERPINC1 Antithrombin-III

Protein Summary

Description

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]

Uniprot Accession IDs

• P01008
• B2R6P0
• P78439
• P78447
• Q13815
• Q5TC78
• Q7KZ43
• Q7KZ97
• Q9UC78
• ATIII

Gene Name

• SERPINC1

Ensembl ID

• ENST00000367698
• ENSP00000356671
• ENSG00000117601

Symbol

• AT3
• AT3
• AT3D
• ATIII
• THPH7
• ATIII-R2
• ATIII-T1
• ATIII-T2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.83
biological term	0.8
chemical	0.72
disease	0.7
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Antithrombin-iii

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Antithrombin-iii

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11467.56   (req: < 5)

Gene RIFs: 119   (req: <= 3)

Antibodies: 764   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11467.56   (req: >= 5)

Gene RIFs: 119   (req: > 3)

Antibodies: 764   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (3)

Explore Approved Drugs

1 – 3 of 3

fondaparinux

SERPINC1Tclin

ACTIVATOR pKd : 7.49

heparin

SERPINC1Tclin

ACTIVATOR pKd : 7.85

enoxaparin sodium

SERPINC1Tclin

ACTIVATOR :

Active Ligands (7)

Explore Active Ligands

1 – 7 of 7

CHEMBL51173

SERPINC1Tclin

pKi : 6.16

CHEMBL1909451

SERPINC1Tclin

pKd : 8.15

CHEMBL609990

SERPINC1Tclin

pKd : 7.24

heparin

SERPINC1Tclin

pKd : 7.85

Idraparinux Sodium

SERPINC1Tclin

pKd : 9

Pentasaccharide analogue

SERPINC1Tclin

pKd : 8.72

Pentasaccharide analogue

SERPINC1Tclin

pKd : 8.55

Protein-Protein Interactions (285)

Explore Interacting Targets

1 – 10 of 285

• See Interactions on String-DB

TUBB1

Tclin

Novelty:  0.02806117

p_int:  0.999194617

p_ni:  0.000805383

Score:  0.16

Data Source:  BioPlex,STRINGDB

TEX15

Tbio

Novelty:  0.08059572

p_int:  0.991982236

p_ni:  0.000214932

p_wrong:  0.007802832

Score:  0.309

Data Source:  BioPlex,STRINGDB

PMCH

Tbio

Novelty:  0.00600873

p_int:  0.986092257

p_ni:  0.013901804

p_wrong:  0.000005939

Data Source:  BioPlex

DDX31

Tbio

Family:  Enzyme

Novelty:  2.84646195

p_int:  0.969817352

p_ni:  0.030173961

p_wrong:  0.000008687

Data Source:  BioPlex

BTD

Tbio

Family:  Enzyme

Novelty:  0.01638573

p_int:  0.965190884

p_ni:  0.034808677

p_wrong:  4.4e-7

Score:  0.37

Data Source:  BioPlex,STRINGDB

FCGRT

Tclin

Novelty:  0.00105713

p_int:  0.94329349

p_ni:  0.055312475

p_wrong:  0.001394035

Score:  0.201

Data Source:  BioPlex,STRINGDB

SUCLG1

Tbio

Family:  Enzyme

Novelty:  0.01113643

p_int:  0.941102237

p_ni:  0.058897763

Score:  0.518

Data Source:  BioPlex,STRINGDB

OS9

Tbio

Novelty:  0.01490339

p_int:  0.81686114

p_ni:  0.18313886

Score:  0.162

Data Source:  BioPlex,STRINGDB

CBWD1

Tbio

Novelty:  0.04321511

p_int:  0.805411519

p_ni:  0.19458848

p_wrong:  1e-9

Score:  0.187

Data Source:  BioPlex,STRINGDB

F9

Tchem

Family:  Enzyme

Novelty:  0.00032127

Score:  0.999

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (13)

Reactome (8)

KEGG (1)

PathwayCommons (2)

WikiPathways (2)

Common Pathway of Fibrin Clot Formation (R-HSA-140875)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Common Pathway of Fibrin Clot Formation	22 targets	R-HSA-140875
Reactome	Formation of Fibrin Clot (Clotting Cascade)	39 targets	R-HSA-140877
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Intrinsic Pathway of Fibrin Clot Formation	22 targets	R-HSA-140837
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Common Pathway of Fibrin Clot Formation	22 targets	R-HSA-140875
Formation of Fibrin Clot (Clotting Cascade)	39 targets	R-HSA-140877
Hemostasis	666 targets	R-HSA-109582
Intrinsic Pathway of Fibrin Clot Formation	22 targets	R-HSA-140837
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (4)

Components (7)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protease binding	Inferred from Physical Interaction (IPI)	UniProtKB
serine-type endopeptidase inhibitor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
heparin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (13)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	2	2		68
red blood cell density measurement	EFO_0007978	1	1	1		66
alcohol consumption measurement	EFO_0007878	3	1	3		56.4
hemoglobin measurement	EFO_0004509	2	1	2		54.4
hematocrit	EFO_0004348	2	1	2		53.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2		68
red blood cell density measurement	EFO_0007978	1		66
alcohol consumption measurement	EFO_0007878	3		56.4
hemoglobin measurement	EFO_0004509	2		54.4
hematocrit	EFO_0004348	2		53.3

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Blood coagulation
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hemostasis
Heparin-binding
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
alcohol consumption measurement
chronotype measurement
depressive symptom measurement
feeling miserable measurement
heel bone mineral density
hematocrit
hemoglobin measurement
IGF-1 measurement
insomnia measurement
mathematical ability

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
embryo phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
mortality/aging
muscle phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	serpin family C member 1	VGNC:9954	457528
Macaque	serpin family C member 1		708854
Mouse	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	MGI:88095	11905
Dog	serpin family C member 1	VGNC:46034	480066
Horse	serpin family C member 1	VGNC:22854	100061173

Species	Name	OMA	EggNOG	Inparanoid
Chimp	serpin family C member 1
Macaque	serpin family C member 1
Mouse	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
Dog	serpin family C member 1
Horse	serpin family C member 1

Publication Statistics

PubMed Score 11467.56

PubMed score by year

Reset Zoom

PubTator Score 7153.86

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (233)

GeneRif Annotations (119)

Items per page:

10

0 of 0

PMID	Year	Title