Protein Summary
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]
- ENST00000367698
- ENSP00000356671
- ENSG00000117601
- AT3
- AT3
- AT3D
- ATIII
- THPH7
- ATIII-R2
- ATIII-T1
- ATIII-T2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.83 | ||
biological term | 0.8 | ||
chemical | 0.72 | ||
disease | 0.7 | ||
virus perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11467.56 (req: < 5)
Gene RIFs: 119 (req: <= 3)
Antibodies: 764 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11467.56 (req: >= 5)
Gene RIFs: 119 (req: > 3)
Antibodies: 764 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 7
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (7)
Protein-Protein Interactions (285)
TUBB1
Novelty: 0.02806117
p_int: 0.999194617
p_ni: 0.000805383
Score: 0.16
Data Source: BioPlex,STRINGDB
TEX15
Novelty: 0.08059572
p_int: 0.991982236
p_ni: 0.000214932
p_wrong: 0.007802832
Score: 0.309
Data Source: BioPlex,STRINGDB
PMCH
Novelty: 0.00600873
p_int: 0.986092257
p_ni: 0.013901804
p_wrong: 0.000005939
Data Source: BioPlex
DDX31
Family: Enzyme
Novelty: 2.84646195
p_int: 0.969817352
p_ni: 0.030173961
p_wrong: 0.000008687
Data Source: BioPlex
BTD
Family: Enzyme
Novelty: 0.01638573
p_int: 0.965190884
p_ni: 0.034808677
p_wrong: 4.4e-7
Score: 0.37
Data Source: BioPlex,STRINGDB
FCGRT
Novelty: 0.00105713
p_int: 0.94329349
p_ni: 0.055312475
p_wrong: 0.001394035
Score: 0.201
Data Source: BioPlex,STRINGDB
SUCLG1
Family: Enzyme
Novelty: 0.01113643
p_int: 0.941102237
p_ni: 0.058897763
Score: 0.518
Data Source: BioPlex,STRINGDB
OS9
Novelty: 0.01490339
p_int: 0.81686114
p_ni: 0.18313886
Score: 0.162
Data Source: BioPlex,STRINGDB
CBWD1
Novelty: 0.04321511
p_int: 0.805411519
p_ni: 0.19458848
p_wrong: 1e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (13)
Reactome (8)
KEGG (1)
PathwayCommons (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Common Pathway of Fibrin Clot Formation | ||||
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Reactome | Hemostasis | ||||
Reactome | Intrinsic Pathway of Fibrin Clot Formation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Common Pathway of Fibrin Clot Formation | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
Hemostasis | ||||
Intrinsic Pathway of Fibrin Clot Formation | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (4)
Components (7)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 2 | 2 | 68 | |||||
red blood cell density measurement | 1 | 1 | 1 | 66 | |||||
alcohol consumption measurement | 3 | 1 | 3 | 56.4 | |||||
hemoglobin measurement | 2 | 1 | 2 | 54.4 | |||||
hematocrit | 2 | 1 | 2 | 53.3 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 68 | |||||
red blood cell density measurement | 1 | 66 | |||||
alcohol consumption measurement | 3 | 56.4 | |||||
hemoglobin measurement | 2 | 54.4 | |||||
hematocrit | 2 | 53.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | serpin family C member 1 | VGNC:9954 | 457528 | |||||
Macaque | serpin family C member 1 | 708854 | ||||||
Mouse | MGI:88095 | 11905 | ||||||
Dog | serpin family C member 1 | VGNC:46034 | 480066 | |||||
Horse | serpin family C member 1 | VGNC:22854 | 100061173 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | serpin family C member 1 | |||||
Macaque | serpin family C member 1 | |||||
Mouse | ||||||
Dog | serpin family C member 1 | |||||
Horse | serpin family C member 1 | |||||
Publication Statistics
PubMed Score 11467.56
PubMed score by year
PubTator Score 7153.86
PubTator score by year
Related Publications
Text Mined References (233)
GeneRif Annotations (119)
Items per page:
0 of 0
PMID | Year | Title |
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