Pharos : Target Details

Tbio

Protein Summary

Description

Has an important role in epithelial desmosome-mediated cell-cell adhesion. The protein encoded by this gene is a member of the ov-serpin family of serine protease inhibitors. The encoded protein is produced by platelets and can bind to and inhibit the function of furin, a serine protease involved in platelet functions. In addition, this protein has been found to enhance the mechanical stability of cell-cell adhesion in the skin, and defects in this gene have been associated with an autosomal-recessive form of exfoliative ichthyosis. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

Gene Name

SERPINB8

Ensembl ID

ENST00000353706
ENSP00000331368
ENSG00000166401
ENST00000397985
ENSP00000381072
ENST00000397988
ENSP00000381075
ENST00000542677
ENSP00000438328

Symbol

PI8
PI8
CAP2
PI-8
PSS5
C18orf53

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.81

tissue sample	0.68

cell type or tissue	0.62

interacting protein	0.62

microRNA	0.62

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.28 (req: < 5)

View Publications

Gene RIFs: 6 (req: <= 3)

View Gene RIFs

Antibodies: 250 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.28 (req: >= 5)

Gene RIFs: 6 (req: > 3)

Antibodies: 250 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (91)

Explore Interacting Targets

1 – 10 of 91

See Interactions on String-DB

SERPINB6

Tbio

Novelty: 0.00568825

p_int: 0.999999888

p_ni: 1.6e-8

p_wrong: 9.6e-8

Score: 0.346

Data Source: BioPlex,STRINGDB

TBC1D22B

Tbio

Novelty: 0.49852962

p_int: 0.999900054

p_ni: 0.000099946

Data Source: BioPlex

CFAP298

Tbio

Novelty: 0.1550579

p_int: 0.99856975

p_ni: 0.00143025

Score: 0.183

Data Source: BioPlex,STRINGDB

HES4

Tbio

Family: TF

Novelty: 0.05290912

p_int: 0.995393751

p_ni: 0.004552245

p_wrong: 0.000054004

Data Source: BioPlex

NONO

Tbio

Novelty: 0.00501502

p_int: 0.994776172

p_ni: 0.005223828

Score: 0.179

Data Source: BioPlex,STRINGDB

FCF1

Tdark

Novelty: 0.04202976

p_int: 0.991021747

p_ni: 0.00894067

p_wrong: 0.000037584

Data Source: BioPlex

NDUFS5

Tclin

Family: Enzyme

Novelty: 0.13274675

p_int: 0.985037572

p_ni: 0.004501395

p_wrong: 0.010461033

Data Source: BioPlex

GPATCH2L

Tdark

Novelty: 1.68490464

p_int: 0.98196502

p_ni: 0.017927814

p_wrong: 0.000107166

Score: 0.173

Data Source: BioPlex,STRINGDB

CDK15

Tchem

Family: Kinase

Novelty: 0.3870338

p_int: 0.981019906

p_ni: 0.018975574

p_wrong: 0.00000452

Data Source: BioPlex

FAM102A

Tdark

Novelty: 0.32284443

p_int: 0.978073253

p_ni: 0.021925889

p_wrong: 8.58e-7

Score: 0.39

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

Reactome (2)

Dissolution of Fibrin Clot (R-HSA-75205)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Dissolution of Fibrin Clot	13 targets	R-HSA-75205

Reactome	Hemostasis	666 targets	R-HSA-109582

Name	Explore in Pharos	Explore in Source
Dissolution of Fibrin Clot	13 targets	R-HSA-75205

Hemostasis	666 targets	R-HSA-109582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (1)

Components (5)

Processes (2)

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GO Term	Evidence	Assigned by
serine-type endopeptidase inhibitor activity	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword

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No Header	No Header
Alternative splicing

Complete proteome

Cytoplasm

Polymorphism

Protease inhibitor

Reference proteome

Serine protease inhibitor

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID
Chimp	serpin family B member 8	VGNC:9947	107969517

Macaque	serpin B8		100424017

Mouse	serine (or cysteine) peptidase inhibitor, clade B, member 8	MGI:894657	20725

Rat	serpin family B member 8	RGD:1309833	288937

Dog	serpin family B member 8	VGNC:53976	607205

Species	Name	OMA	EggNOG	Inparanoid
Chimp	serpin family B member 8

Macaque	serpin B8

Mouse	serine (or cysteine) peptidase inhibitor, clade B, member 8

Rat	serpin family B member 8

Dog	serpin family B member 8

Publication Statistics

PubMed Score 30.28

PubMed score by year

PubTator Score 22.72

PubTator score by year

Related Publications

Text Mined References (23)

GeneRif Annotations (6)

Items per page:

0 of 0

PMID	Year	Title