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Tbio
SERPINB7
Serpin B7

Protein Summary
Description
Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin. This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336429
  • ENSP00000337212
  • ENSG00000166396
  • ENST00000398019
  • ENSP00000381101
  • ENST00000540675
  • ENSP00000444572
  • ENST00000546027
  • ENSP00000444861

Symbol
  • PPKN
  • TP55
  • MEGSIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.8
transcription factor
0.57
biological process
0.54
cell line
0.5
microRNA
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.46   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.46   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
KIR3DS1
Tdark
p_int:  0.999961105
p_ni:  0.000038895
Data Source:  BioPlex
GDF5
Tbio
Novelty:  0.00218118
p_int:  0.999900414
p_ni:  0.000099586
Score:  0.166
Data Source:  BioPlex,STRINGDB
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
p_int:  0.999828869
p_ni:  0.00017113
p_wrong:  1e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
FTH1
Tbio
Novelty:  0.000863
p_int:  0.999568868
p_ni:  0.00043113
p_wrong:  1e-9
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.999453151
p_ni:  0.000546846
p_wrong:  3e-9
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.999316154
p_ni:  0.000683843
p_wrong:  3e-9
Score:  0.156
Data Source:  BioPlex,STRINGDB
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.999127294
p_ni:  0.000387631
p_wrong:  0.000485074
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.999081151
p_ni:  0.000917728
p_wrong:  0.000001121
Data Source:  BioPlex
NONO
Tbio
Novelty:  0.00501502
p_int:  0.998408795
p_ni:  0.001591201
p_wrong:  3e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.9956497
p_ni:  0.003634495
p_wrong:  0.000715805
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
2
75.4
age at onset
1
1
1
75.3
childhood onset asthma
2
1
0
1.3
69.2
vitamin D measurement
3
1
3
46.9
2
1
0
1.1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
75.4
age at onset
1
75.3
childhood onset asthma
0
1.3
69.2
vitamin D measurement
3
46.9
0
1.1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family B member 7
VGNC:9948
107966354
Macaque
serpin family B member 7
701671
Mouse
MGI:2151053
116872
Rat
RGD:71063
117092
Dog
serpin family B member 7
VGNC:46032
483952
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family B member 7
Macaque
serpin family B member 7
Mouse
Rat
Dog
serpin family B member 7
Publication Statistics
PubMed Score 66.46
PubMed score by year
PubTator Score 47.12
PubTator score by year
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Related Publications
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PMID
Year
Title