Tbio SERPINB7 Serpin B7

Protein Summary

Description

Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin. This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Uniprot Accession IDs

• O75635
• B4DUW8
• F5GZC0
• Q1ED45
• Q3KPG4

Gene Name

• SERPINB7

Ensembl ID

• ENST00000336429
• ENSP00000337212
• ENSG00000166396
• ENST00000398019
• ENSP00000381101
• ENST00000540675
• ENSP00000444572
• ENST00000546027
• ENSP00000444861

Symbol

• PPKN
• TP55
• MEGSIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.8
transcription factor	0.57
biological process	0.54
cell line	0.5
microRNA	0.48

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Serpin B7

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Serpin B7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.46   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 172   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.46   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (77)

Explore Interacting Targets

1 – 10 of 77

• See Interactions on String-DB

KIR3DS1

Tdark

p_int:  0.999961105

p_ni:  0.000038895

Data Source:  BioPlex

GDF5

Tbio

Novelty:  0.00218118

p_int:  0.999900414

p_ni:  0.000099586

Score:  0.166

Data Source:  BioPlex,STRINGDB

PI4KA

Tchem

Family:  Kinase

Novelty:  0.01701469

p_int:  0.999828869

p_ni:  0.00017113

p_wrong:  1e-9

Score:  0.179

Data Source:  BioPlex,STRINGDB

FTH1

Tbio

Novelty:  0.000863

p_int:  0.999568868

p_ni:  0.00043113

p_wrong:  1e-9

Data Source:  BioPlex

TBC1D22B

Tbio

Novelty:  0.49852962

p_int:  0.999453151

p_ni:  0.000546846

p_wrong:  3e-9

Data Source:  BioPlex

CDK15

Tchem

Family:  Kinase

Novelty:  0.3870338

p_int:  0.999316154

p_ni:  0.000683843

p_wrong:  3e-9

Score:  0.156

Data Source:  BioPlex,STRINGDB

DDX19B

Tbio

Family:  Enzyme

Novelty:  0.0504568

p_int:  0.999127294

p_ni:  0.000387631

p_wrong:  0.000485074

Data Source:  BioPlex

KLHL11

Tbio

Novelty:  0.1537041

p_int:  0.999081151

p_ni:  0.000917728

p_wrong:  0.000001121

Data Source:  BioPlex

NONO

Tbio

Novelty:  0.00501502

p_int:  0.998408795

p_ni:  0.001591201

p_wrong:  3e-9

Score:  0.173

Data Source:  BioPlex,STRINGDB

TEFM

Tbio

Novelty:  0.10836617

p_int:  0.9956497

p_ni:  0.003634495

p_wrong:  0.000715805

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (1)

Components (2)

Processes (5)

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GO Term	Evidence	Assigned by
serine-type endopeptidase inhibitor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
allergy	EFO_0003785	2	1	2		75.4
age at onset	EFO_0004847	1	1	1		75.3
childhood onset asthma	EFO_0004591	2	1	0	1.3	69.2
vitamin D measurement	EFO_0004631	3	1	3		46.9
asthma	EFO_0000270	2	1	0	1.1	33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
allergy	EFO_0003785	2		75.4
age at onset	EFO_0004847	1		75.3
childhood onset asthma	EFO_0004591	0	1.3	69.2
vitamin D measurement	EFO_0004631	3		46.9
asthma	EFO_0000270	0	1.1	33.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Cytoplasm
Palmoplantar keratoderma
Phosphoprotein
Polymorphism
Protease inhibitor
Reference proteome
Serine protease inhibitor

GWAS Trait Find Similar Targets

No Header	No Header
age at onset
allergy
asthma
childhood onset asthma
food allergy measurement
vitamin D measurement

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	serpin family B member 7	VGNC:9948	107966354
Macaque	serpin family B member 7		701671
Mouse	serine (or cysteine) peptidase inhibitor, clade B, member 7	MGI:2151053	116872
Rat	serpin family B member 7	RGD:71063	117092
Dog	serpin family B member 7	VGNC:46032	483952

Species	Name	OMA	EggNOG	Inparanoid
Chimp	serpin family B member 7
Macaque	serpin family B member 7
Mouse	serine (or cysteine) peptidase inhibitor, clade B, member 7
Rat	serpin family B member 7
Dog	serpin family B member 7

Publication Statistics

PubMed Score 66.46

PubMed score by year

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PubTator Score 47.12

PubTator score by year

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Related Publications

Text Mined References (37)

GeneRif Annotations (25)

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10

0 of 0

PMID	Year	Title