Tbio SERPINB5 Serpin B5

Protein Summary

Description

Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Uniprot Accession IDs

• P36952
• B2R6Y4
• Q6N0B4
• Q8WW89

Gene Name

• SERPINB5

Ensembl ID

• ENST00000382771
• ENSP00000372221
• ENSG00000206075
• ENST00000489441
• ENSP00000467158

Symbol

• PI5
• PI5
• maspin

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.73
gene perturbation	0.67
biological term	0.61
small molecule perturbation	0.61
microRNA	0.6

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Serpin B5

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Serpin B5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 642.96   (req: < 5)

Gene RIFs: 205   (req: <= 3)

Antibodies: 508   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 642.96   (req: >= 5)

Gene RIFs: 205   (req: > 3)

Antibodies: 508   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0