Protein Summary
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
- ENST00000382771
- ENSP00000372221
- ENSG00000206075
- ENST00000489441
- ENSP00000467158
- PI5
- PI5
- maspin
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.73 | ||
gene perturbation | 0.67 | ||
biological term | 0.61 | ||
small molecule perturbation | 0.61 | ||
microRNA | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 599.28 (req: < 5)
Gene RIFs: 205 (req: <= 3)
Antibodies: 508 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 599.28 (req: >= 5)
Gene RIFs: 205 (req: > 3)
Antibodies: 508 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (161)
FCF1
Novelty: 0.04202976
p_int: 0.999777778
p_ni: 0.000222219
p_wrong: 3e-9
Data Source: BioPlex
MMP14
Family: Enzyme
Novelty: 0.00083836
p_int: 0.997872658
p_ni: 0.002127342
Data Source: BioPlex
DDX19B
Family: Enzyme
Novelty: 0.0504568
p_int: 0.997774638
p_ni: 0.002225362
Data Source: BioPlex
CDK15
Family: Kinase
Novelty: 0.3870338
p_int: 0.997471483
p_ni: 0.002528515
p_wrong: 2e-9
Data Source: BioPlex
EIF2A
Novelty: 0.08652858
p_int: 0.996755446
p_ni: 0.003032277
p_wrong: 0.000212276
Score: 0.183
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
KEGG (2)
PathwayCommons (3)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | p53 signaling pathway | ||||
KEGG | MicroRNAs in cancer | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
p53 signaling pathway | ||||
MicroRNAs in cancer | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (1)
Components (2)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 2 | 2 | 81.5 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 2 | 75.3 | |||||
eosinophil percentage of granulocytes | 1 | 1 | 1 | 8.2 | |||||
sum of eosinophil and basophil counts | 1 | 1 | 1 | 7.9 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 81.5 | |||||
eosinophil percentage of leukocytes | 2 | 75.3 | |||||
eosinophil percentage of granulocytes | 1 | 8.2 | |||||
sum of eosinophil and basophil counts | 1 | 7.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | serpin family B member 5 | VGNC:9949 | 468566 | |||||
Macaque | serpin family B member 5 | 700713 | ||||||
Mouse | MGI:109579 | 20724 | ||||||
Rat | RGD:69342 | 116589 | ||||||
Dog | serpin family B member 5 | VGNC:46031 | 476177 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | serpin family B member 5 | |||||
Macaque | serpin family B member 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | serpin family B member 5 | |||||
Publication Statistics
PubMed Score 599.28
PubMed score by year
PubTator Score 399.00
PubTator score by year
Related Publications
Text Mined References (217)
GeneRif Annotations (205)
Items per page:
0 of 0
PMID | Year | Title |
|---|