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Tbio
SERPINB4
Serpin B4

Protein Summary
Description
May act as a protease inhibitor to modulate the host immune response against tumor cells. The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341074
  • ENSP00000343445
  • ENSG00000206073

Symbol
  • PI11
  • SCCA2
  • PI11
  • SCCA1
  • SCCA2
  • LEUPIN
  • SCCA-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
cell type or tissue
0.84
gene perturbation
0.75
interacting protein
0.74
cell line
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.62   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 378   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.62   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0