Protein Summary
May act as a protease inhibitor to modulate the host immune response against tumor cells. The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]
- ENST00000341074
- ENSP00000343445
- ENSG00000206073
- PI11
- SCCA2
- PI11
- SCCA1
- SCCA2
- LEUPIN
- SCCA-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.92 | ||
cell type or tissue | 0.84 | ||
gene perturbation | 0.75 | ||
interacting protein | 0.74 | ||
cell line | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 184.51 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 378 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 184.51 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 378 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (69)
ZSCAN20
Family: TF
Novelty: 0.37441538
p_int: 0.999453245
p_ni: 0.000546752
p_wrong: 3e-9
Data Source: BioPlex
DDX19B
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999342788
p_ni: 0.000657212
Data Source: BioPlex
UGT1A10
Family: Enzyme
Novelty: 0.01535804
p_int: 0.996451839
p_ni: 0.003548161
Data Source: BioPlex
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Amoebiasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amoebiasis | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (3)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 2 | 2 | 81.5 | |||||
vitamin D measurement | 3 | 1 | 3 | 46.9 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 9.6 | |||||
eosinophil percentage of granulocytes | 1 | 1 | 1 | 8.2 | |||||
sum of eosinophil and basophil counts | 1 | 1 | 1 | 7.9 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 81.5 | |||||
vitamin D measurement | 3 | 46.9 | |||||
eosinophil percentage of leukocytes | 1 | 9.6 | |||||
eosinophil percentage of granulocytes | 1 | 8.2 | |||||
sum of eosinophil and basophil counts | 1 | 7.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Horse | serpin B4-like | 100051371 | ||||||
Cow | serpin family B member 4 | 618956 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Horse | serpin B4-like | |||||
Cow | serpin family B member 4 | |||||
Publication Statistics
PubMed Score 184.51
PubMed score by year
PubTator Score 60.75
PubTator score by year
Related Publications
Text Mined References (58)
GeneRif Annotations (39)
Items per page:
0 of 0
PMID | Year | Title |
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