Tbio SERPINB4 Serpin B4

Protein Summary

Description

May act as a protease inhibitor to modulate the host immune response against tumor cells. The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• P48594
• A8K847

Gene Name

• SERPINB4

Ensembl ID

• ENST00000341074
• ENSP00000343445
• ENSG00000206073

Symbol

• PI11
• SCCA2
• PI11
• SCCA1
• SCCA2
• LEUPIN
• SCCA-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.92
cell type or tissue	0.84
gene perturbation	0.75
interacting protein	0.74
cell line	0.66

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Serpin B4

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Serpin B4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.62   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 378   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.62   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0