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Tbio
SERPINB4
Serpin B4

Protein Summary
Description
May act as a protease inhibitor to modulate the host immune response against tumor cells. The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341074
  • ENSP00000343445
  • ENSG00000206073

Symbol
  • PI11
  • SCCA2
  • PI11
  • SCCA1
  • SCCA2
  • LEUPIN
  • SCCA-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
cell type or tissue
0.84
gene perturbation
0.75
interacting protein
0.74
cell line
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.51   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 378   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.51   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
SERPINB3
Tbio
Novelty:  0.00325244
p_int:  1
Score:  0.992
Data Source:  BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.999869218
p_ni:  0.000130781
Data Source:  BioPlex
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.999455355
p_ni:  0.000544645
Data Source:  BioPlex
ZSCAN20
Tdark
Family:  TF
Novelty:  0.37441538
p_int:  0.999453245
p_ni:  0.000546752
p_wrong:  3e-9
Data Source:  BioPlex
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.999342788
p_ni:  0.000657212
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.99910347
p_ni:  0.00089653
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.998937339
p_ni:  0.001062661
Data Source:  BioPlex
ITGA9
Tbio
Novelty:  0.01488635
p_int:  0.997425268
p_ni:  0.002574732
Data Source:  BioPlex
KIR3DS1
Tdark
p_int:  0.996865533
p_ni:  0.003134467
Data Source:  BioPlex
UGT1A10
Tbio
Family:  Enzyme
Novelty:  0.01535804
p_int:  0.996451839
p_ni:  0.003548161
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
81.5
vitamin D measurement
3
1
3
46.9
eosinophil percentage of leukocytes
1
1
1
9.6
eosinophil percentage of granulocytes
1
1
1
8.2
sum of eosinophil and basophil counts
1
1
1
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
81.5
vitamin D measurement
3
46.9
eosinophil percentage of leukocytes
1
9.6
eosinophil percentage of granulocytes
1
8.2
sum of eosinophil and basophil counts
1
7.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Horse
serpin B4-like
100051371
Cow
serpin family B member 4
618956
Species
Name
OMA
EggNOG
Inparanoid
Horse
serpin B4-like
Cow
serpin family B member 4
Publication Statistics
PubMed Score 184.51
PubMed score by year
PubTator Score 60.75
PubTator score by year
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Related Publications
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PMID
Year
Title