Protein Summary
May play a role in the proliferation or differentiation of keratinocytes. The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein inhibits the activity of cathepsin K and is itself transcriptionally repressed by RUNX1. This gene is downregulated in many types of cancer. [provided by RefSeq, Jan 2017]
- ENST00000344731
- ENSP00000341584
- ENSG00000197641
- PI13
- HUR7
- PI13
- headpin
- HSHUR7SEQ
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.71 | ||
kinase perturbation | 0.71 | ||
virus perturbation | 0.64 | ||
interacting protein | 0.61 | ||
gene perturbation | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 54.15 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 190 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 54.15 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 190 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (48)
ROR1
Family: Kinase
Novelty: 0.03038955
p_int: 0.999996804
p_ni: 0.00000311
p_wrong: 8.5e-8
Score: 0.29
Data Source: BioPlex,STRINGDB
BSDC1
Novelty: 1.591335
p_int: 0.999991454
p_ni: 8e-9
p_wrong: 0.000008538
Score: 0.291
Data Source: BioPlex,STRINGDB
BRAP
Novelty: 0.0285957
p_int: 0.999972571
p_ni: 0.000027414
p_wrong: 1.4e-8
Score: 0.202
Data Source: BioPlex,STRINGDB
C1orf198
Novelty: 3.89427313
p_int: 0.999808766
p_ni: 0.000182099
p_wrong: 0.000009135
Data Source: BioPlex
RNF34
Family: Enzyme
Novelty: 0.04365307
p_int: 0.999317273
p_ni: 0.000088047
p_wrong: 0.00059468
Score: 0.185
Data Source: BioPlex,STRINGDB
RBM14
Novelty: 0.01286049
p_int: 0.998947061
p_ni: 0.001051393
p_wrong: 0.000001547
Data Source: BioPlex
RBM24
Novelty: 0.04562076
p_int: 0.995312346
p_ni: 0.004687635
p_wrong: 1.9e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
C9orf78
Novelty: 0.63248782
p_int: 0.990237822
p_ni: 0.005838345
p_wrong: 0.003923833
Data Source: BioPlex
TTC4
Novelty: 0.00808711
p_int: 0.989425344
p_ni: 0.010574655
Score: 0.173
Data Source: BioPlex,STRINGDB
ADD2
Family: Enzyme
Novelty: 0.01097975
p_int: 0.988063175
p_ni: 0.011936172
p_wrong: 6.53e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (6)
Reactome (5)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | RUNX1 regulates transcription of genes involved in differentiation of keratinocytes | ||||
Reactome | Transcriptional regulation by RUNX1 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes | ||||
Transcriptional regulation by RUNX1 | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (3)
Components (7)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 2 | 2 | 81.5 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 2 | 75.3 | |||||
vitamin D measurement | 3 | 1 | 3 | 46.9 | |||||
eosinophil percentage of granulocytes | 1 | 1 | 1 | 8.2 | |||||
sum of eosinophil and basophil counts | 1 | 1 | 1 | 7.9 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
eosinophil count | 2 | 81.5 | |||||
eosinophil percentage of leukocytes | 2 | 75.3 | |||||
vitamin D measurement | 3 | 46.9 | |||||
eosinophil percentage of granulocytes | 1 | 8.2 | |||||
sum of eosinophil and basophil counts | 1 | 7.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | serpin family B member 13 | VGNC:9951 | 738734 | |||||
Macaque | serpin family B member 13 | 701078 | ||||||
Mouse | MGI:3042250 | 241196 | ||||||
Rat | RGD:1304661 | 304690 | ||||||
Dog | serpin family B member 13 | VGNC:46029 | 483955 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | serpin family B member 13 | |||||
Macaque | serpin family B member 13 | |||||
Mouse | ||||||
Rat | ||||||
Dog | serpin family B member 13 | |||||
Publication Statistics
PubMed Score 54.15
PubMed score by year
PubTator Score 15.84
PubTator score by year
Related Publications
Text Mined References (20)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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