Tbio SERPINB13 Serpin B13

Protein Summary

Description

May play a role in the proliferation or differentiation of keratinocytes. The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein inhibits the activity of cathepsin K and is itself transcriptionally repressed by RUNX1. This gene is downregulated in many types of cancer. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• Q9UIV8
• A8K2Q8
• Q3MII2
• Q9HCX1
• Q9UBW1
• Q9UKG0

Gene Name

• SERPINB13

Ensembl ID

• ENST00000344731
• ENSP00000341584
• ENSG00000197641

Symbol

• PI13
• HUR7
• PI13
• headpin
• HSHUR7SEQ

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.71
kinase perturbation	0.71
virus perturbation	0.64
interacting protein	0.61
gene perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Serpin B13

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Serpin B13

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.15   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 190   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.15   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (48)

Explore Interacting Targets

1 – 10 of 48

• See Interactions on String-DB

ROR1

Tbio

Family:  Kinase

Novelty:  0.03038955

p_int:  0.999996804

p_ni:  0.00000311

p_wrong:  8.5e-8

Score:  0.29

Data Source:  BioPlex,STRINGDB

BSDC1

Tdark

Novelty:  1.591335

p_int:  0.999991454

p_ni:  8e-9

p_wrong:  0.000008538

Score:  0.291

Data Source:  BioPlex,STRINGDB

BRAP

Tbio

Novelty:  0.0285957

p_int:  0.999972571

p_ni:  0.000027414

p_wrong:  1.4e-8

Score:  0.202

Data Source:  BioPlex,STRINGDB

C1orf198

Tdark

Novelty:  3.89427313

p_int:  0.999808766

p_ni:  0.000182099

p_wrong:  0.000009135

Data Source:  BioPlex

RNF34

Tbio

Family:  Enzyme

Novelty:  0.04365307

p_int:  0.999317273

p_ni:  0.000088047

p_wrong:  0.00059468

Score:  0.185

Data Source:  BioPlex,STRINGDB

RBM14

Tbio

Novelty:  0.01286049

p_int:  0.998947061

p_ni:  0.001051393

p_wrong:  0.000001547

Data Source:  BioPlex

RBM24

Tbio

Novelty:  0.04562076

p_int:  0.995312346

p_ni:  0.004687635

p_wrong:  1.9e-8

Score:  0.187

Data Source:  BioPlex,STRINGDB

C9orf78

Tdark

Novelty:  0.63248782

p_int:  0.990237822

p_ni:  0.005838345

p_wrong:  0.003923833

Data Source:  BioPlex

TTC4

Tbio

Novelty:  0.00808711

p_int:  0.989425344

p_ni:  0.010574655

Score:  0.173

Data Source:  BioPlex,STRINGDB

ADD2

Tbio

Family:  Enzyme

Novelty:  0.01097975

p_int:  0.988063175

p_ni:  0.011936172

p_wrong:  6.53e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (5)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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Find Similar Targets

Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857
Reactome	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	8 targets	R-HSA-8939242
Reactome	Transcriptional regulation by RUNX1	208 targets	R-HSA-8878171

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	8 targets	R-HSA-8939242
Transcriptional regulation by RUNX1	208 targets	R-HSA-8878171

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (3)

Components (7)

Processes (5)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
cysteine-type endopeptidase inhibitor activity	Inferred from Direct Assay (IDA)	UniProtKB
protease binding	Inferred from Physical Interaction (IPI)	UniProtKB
serine-type endopeptidase inhibitor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	2	2	2		81.5
eosinophil percentage of leukocytes	EFO_0007991	2	2	2		75.3
vitamin D measurement	EFO_0004631	3	1	3		46.9
eosinophil percentage of granulocytes	EFO_0007996	1	1	1		8.2
sum of eosinophil and basophil counts	EFO_0009389	1	1	1		7.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	2		81.5
eosinophil percentage of leukocytes	EFO_0007991	2		75.3
vitamin D measurement	EFO_0004631	3		46.9
eosinophil percentage of granulocytes	EFO_0007996	1		8.2
sum of eosinophil and basophil counts	EFO_0009389	1		7.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Cytoplasm
Polymorphism
Protease inhibitor
Reference proteome
Serine protease inhibitor

GWAS Trait Find Similar Targets

No Header	No Header
eosinophil count
eosinophil percentage of granulocytes
eosinophil percentage of leukocytes
sum of eosinophil and basophil counts
vitamin D measurement

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	serpin family B member 13	VGNC:9951	738734
Macaque	serpin family B member 13		701078
Mouse	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13	MGI:3042250	241196
Rat	serpin family B member 13	RGD:1304661	304690
Dog	serpin family B member 13	VGNC:46029	483955

Species	Name	OMA	EggNOG	Inparanoid
Chimp	serpin family B member 13
Macaque	serpin family B member 13
Mouse	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13
Rat	serpin family B member 13
Dog	serpin family B member 13

Publication Statistics

PubMed Score 54.15

PubMed score by year

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PubTator Score 15.84

PubTator score by year

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Related Publications

Text Mined References (20)

GeneRif Annotations (9)

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10

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PMID	Year	Title