Tbio SERPINB13 Serpin B13

Protein Summary

Description

May play a role in the proliferation or differentiation of keratinocytes. The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein inhibits the activity of cathepsin K and is itself transcriptionally repressed by RUNX1. This gene is downregulated in many types of cancer. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• Q9UIV8
• A8K2Q8
• Q3MII2
• Q9HCX1
• Q9UBW1
• Q9UKG0

Gene Name

• SERPINB13

Ensembl ID

• ENST00000344731
• ENSP00000341584
• ENSG00000197641

Symbol

• PI13
• HUR7
• PI13
• headpin
• HSHUR7SEQ

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.71
kinase perturbation	0.71
virus perturbation	0.64
interacting protein	0.61
gene perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Serpin B13

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Serpin B13

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.22   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 190   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.22   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0