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Tchem
SERPINA6
Corticosteroid-binding globulin

Protein Summary
Description
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341584
  • ENSP00000342850
  • ENSG00000170099
  • ENST00000621384
  • ENSP00000484501
  • ENSG00000277405

Symbol
  • CBG
  • CBG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.81
cell type or tissue
0.76
disease
0.63
gene perturbation
0.6
biological term
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1885.62   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 452   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1885.62   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (12)
progesterone
Rendered image for progesterone
prednisolone
Rendered image for prednisolone
testosterone
Rendered image for testosterone
desoxycortone
Rendered image for desoxycortone
hydrocortisone
Rendered image for hydrocortisone
prednisolone tebutate
Rendered image for prednisolone tebutate
cortisone acetate
Rendered image for cortisone acetate
nandrolone
Rendered image for nandrolone
hydroxyprogesterone caproate
Rendered image for hydroxyprogesterone caproate
Protein-Protein Interactions (57)
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.999549682
p_ni:  0.000450317
Score:  0.187
Data Source:  BioPlex,STRINGDB
COCH
Tbio
Novelty:  0.00819355
p_int:  0.801460902
p_ni:  0.198539098
Score:  0.212
Data Source:  BioPlex,STRINGDB
PAM
Tchem
Family:  Enzyme
Novelty:  0.00378397
p_int:  0.799880681
p_ni:  0.200109358
p_wrong:  0.000009961
Score:  0.345
Data Source:  BioPlex,STRINGDB
SHBG
Tchem
Novelty:  0.00015978
Score:  0.839
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.785
Data Source:  STRINGDB
CORT
Tbio
Novelty:  0.00789975
Score:  0.744
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.73
Data Source:  STRINGDB
NR3C1
Tclin
Family:  NR
Novelty:  0.00029396
Score:  0.672
Data Source:  STRINGDB
HSD17B6
Tbio
Family:  Enzyme
Novelty:  0.01428594
Score:  0.64
Data Source:  STRINGDB
CRH
Tbio
Novelty:  0.000147
Score:  0.618
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (90)
Items per page:
1 – 5 of 90
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
8
8
99.5
serum albumin measurement
1
8
8
99.5
sex hormone-binding globulin measurement
6
3
13
98
sex hormone-binding globulin measurement
6
3
13
98
testosterone measurement
6
4
10
97.6
Items per page:
1 – 5 of 90
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
8
99.5
serum albumin measurement
8
99.5
sex hormone-binding globulin measurement
13
98
sex hormone-binding globulin measurement
13
98
testosterone measurement
10
97.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family A member 6
VGNC:12529
453131
Macaque
serpin family A member 6
701121
Mouse
MGI:88278
12401
Rat
RGD:1595901
299270
Dog
serpin family A member 6
VGNC:51683
490838
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family A member 6
Macaque
serpin family A member 6
Mouse
Rat
Dog
serpin family A member 6
Publication Statistics
PubMed Score 1885.62
PubMed score by year
PubTator Score 828.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title