Tbio SERPINA4 Kallistatin

Protein Summary

Description

Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.

Uniprot Accession IDs

• P29622
• Q53XB5
• Q86TR9
• Q96BZ5

Gene Name

• SERPINA4

Ensembl ID

• ENST00000298841
• ENSP00000298841
• ENSG00000100665
• ENST00000555095
• ENSP00000451172
• ENST00000557004
• ENSP00000450838

Symbol

• KST
• PI4
• KAL
• KST
• PI4
• KLST
• PI-4
• kallistatin

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
tissue	0.61
disease perturbation	0.56
cellular component	0.46
cell line	0.44

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Kallistatin

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / Kallistatin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.8   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 204   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.8   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0