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Tbio
SERPINA4
Kallistatin

Protein Summary
Description
Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298841
  • ENSP00000298841
  • ENSG00000100665
  • ENST00000555095
  • ENSP00000451172
  • ENST00000557004
  • ENSP00000450838

Symbol
  • KST
  • PI4
  • KAL
  • KST
  • PI4
  • KLST
  • PI-4
  • kallistatin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
tissue
0.61
disease perturbation
0.56
cellular component
0.46
cell line
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.8   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.8   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0