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Tbio
SERPINA12
Serpin A12

Protein Summary
Description
Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341228
  • ENSP00000342109
  • ENSG00000165953
  • ENST00000556881
  • ENSP00000451738

Symbol
  • OL-64
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
biological term
0.68
biological process
0.54
cell line
0.53
protein complex
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.64   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 336   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.64   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
SUSD5
Tdark
Novelty:  1.0992718
p_int:  0.999986778
p_ni:  0.000005254
p_wrong:  0.000007967
Data Source:  BioPlex
KIAA1549
Tbio
Novelty:  0.01224835
p_int:  0.999959661
p_ni:  0.000037591
p_wrong:  0.000002749
Data Source:  BioPlex
LAMB1
Tbio
Novelty:  0.0104285
p_int:  0.999900328
p_ni:  0.000099672
Score:  0.158
Data Source:  BioPlex,STRINGDB
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.999828982
p_ni:  0.000171007
p_wrong:  1.1e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
FCF1
Tdark
Novelty:  0.04202976
p_int:  0.99965556
p_ni:  0.00034444
Data Source:  BioPlex
FTH1
Tbio
Novelty:  0.000863
p_int:  0.999200938
p_ni:  0.000799062
Data Source:  BioPlex
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.998729765
p_ni:  0.001270172
p_wrong:  6.3e-8
Data Source:  BioPlex
DTL
Tbio
Novelty:  0.01659105
p_int:  0.99845333
p_ni:  0.00154667
Data Source:  BioPlex
TXNDC15
Tdark
Novelty:  0.23488442
p_int:  0.99762375
p_ni:  0.00237625
Data Source:  BioPlex
ZSCAN12
Tdark
Family:  TF
Novelty:  0.33578207
p_int:  0.997363788
p_ni:  0.002636212
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
2
7
7
94.5
vaspin measurement
1
1
1
34.8
blood protein measurement
1
1
1
10.2
anti-neutrophil antibody associated vasculitis
1
1
0
1.7
5.8
alpha fetoprotein measurement
1
1
1
2.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
7
94.5
vaspin measurement
1
34.8
blood protein measurement
1
10.2
anti-neutrophil antibody associated vasculitis
0
1.7
5.8
alpha fetoprotein measurement
1
2.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family A member 12
VGNC:10242
467618
Macaque
serpin family A member 12
701708
Mouse
MGI:1915304
68054
Rat
RGD:708485
191570
Dog
serpin family A member 12
VGNC:51682
612386
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family A member 12
Macaque
serpin family A member 12
Mouse
Rat
Dog
serpin family A member 12
Publication Statistics
PubMed Score 250.64
PubMed score by year
PubTator Score 167.06
PubTator score by year
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Related Publications
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PMID
Year
Title