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Tbio
SERPINA1
Alpha-1-antitrypsin

Protein Summary
Description
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Short peptide from AAT: reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355814
  • ENSP00000348068
  • ENSG00000197249
  • ENST00000393087
  • ENSP00000376802
  • ENST00000393088
  • ENSP00000376803
  • ENST00000402629
  • ENSP00000386094
  • ENST00000404814
  • ENSP00000385960
  • ENST00000437397
  • ENSP00000408474
  • ENST00000440909
  • ENSP00000390299
  • ENST00000448921
  • ENSP00000416066
  • ENST00000449399
  • ENSP00000416354
  • ENST00000489769
  • ENSP00000451525
  • ENST00000636712
  • ENSP00000490054

Symbol
  • AAT
  • PI
  • PI
  • A1A
  • AAT
  • PI1
  • A1AT
  • nNIF
  • PRO2275
  • alpha1AT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
kinase perturbation
0.88
cellular component
0.86
small molecule perturbation
0.83
gene perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7852.95   (req: < 5)
Gene RIFs: 363   (req: <= 3)
Antibodies: 1506   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7852.95   (req: >= 5)
Gene RIFs: 363   (req: > 3)
Antibodies: 1506   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (387)
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999995172
p_ni:  0.000004828
Data Source:  BioPlex
MAPK6
Tchem
Family:  Kinase
Novelty:  0.01012514
p_int:  0.999992378
p_ni:  0.000007622
Data Source:  BioPlex
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999822112
p_ni:  0.000177888
Data Source:  BioPlex
CA8
Tbio
Family:  Enzyme
Novelty:  0.0041859
p_int:  0.999795787
p_ni:  0.000204213
Score:  0.151
Data Source:  BioPlex,STRINGDB
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.999697321
p_ni:  0.000302675
p_wrong:  4e-9
Data Source:  BioPlex
ICE2
Tbio
Novelty:  0.03407933
p_int:  0.999387966
p_ni:  0.000612023
p_wrong:  1.1e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
GDPD1
Tbio
Family:  Enzyme
Novelty:  0.28722153
p_int:  0.998343119
p_ni:  0.001656881
Data Source:  BioPlex
GOT1L1
Tdark
Family:  Enzyme
Novelty:  0.52342415
p_int:  0.996449865
p_ni:  0.003527778
p_wrong:  0.000022357
Score:  0.207
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.99187369
p_ni:  0.008126248
p_wrong:  6.2e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
p_int:  0.991679777
p_ni:  0.008320109
p_wrong:  1.14e-7
Score:  0.273
Data Source:  BioPlex,STRINGDB
Pathways (49)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
ER to Golgi Anterograde Transport
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
ER to Golgi Anterograde Transport
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (68)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
7
4
10
1.5
97.8
serum alanine aminotransferase measurement
4
2
3
6.9
97
blood protein measurement
20
12
23
1.1
96.8
low density lipoprotein cholesterol measurement
10
4
11
96.8
alpha fetoprotein measurement
1
3
3
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
10
1.5
97.8
serum alanine aminotransferase measurement
3
6.9
97
blood protein measurement
23
1.1
96.8
low density lipoprotein cholesterol measurement
11
96.8
alpha fetoprotein measurement
3
95.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family A member 1
467541
Macaque
serpin family A member 1
701361
Mouse
MGI:891967
20704
Mouse
MGI:891969
20702
Rat
RGD:3326
24648
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family A member 1
Macaque
serpin family A member 1
Mouse
Mouse
Rat
Publication Statistics
PubMed Score 7852.95
PubMed score by year
PubTator Score 6647.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title