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Tbio
SERINC1
Serine incorporator 1

Protein Summary
Description
Enhances the incorporation of serine into phosphatidylserine and sphingolipids.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339697
  • ENSP00000342962
  • ENSG00000111897

Symbol
  • KIAA1253
  • TDE1L
  • TDE2
  • TDE2
  • TMS2
  • TDE1L
  • TMS-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
histone modification site profile
0.74
transcription factor perturbation
0.68
gene perturbation
0.67
transcription factor binding site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.6   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.6   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
ASGR2
Tbio
Novelty:  0.14671716
p_int:  0.999740253
p_ni:  0.000259747
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.997287919
p_ni:  0.002712077
p_wrong:  4e-9
Data Source:  BioPlex
NDUFV3
Tclin
Family:  Enzyme
Novelty:  0.15352039
p_int:  0.991119833
p_ni:  0.008880151
p_wrong:  1.6e-8
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.989621631
p_ni:  0.010376243
p_wrong:  0.000002127
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.977800201
p_ni:  0.022189857
p_wrong:  0.000009943
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.975683298
p_ni:  0.023789697
p_wrong:  0.000527005
Data Source:  BioPlex
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.974109985
p_ni:  0.025509192
p_wrong:  0.000380823
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.965718924
p_ni:  0.034281076
Data Source:  BioPlex
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.96107397
p_ni:  0.038925943
p_wrong:  8.7e-8
Score:  0.194
Data Source:  BioPlex,STRINGDB
TMEM63A
Tdark
Family:  IC
Novelty:  0.33131011
p_int:  0.91598463
p_ni:  0.073091678
p_wrong:  0.010923692
Score:  0.159
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Serine biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Serine biosynthesis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
4
93.1
myeloid white cell count
1
1
1
78.5
monocyte count
1
1
1
74.8
platelet crit
2
1
2
71.2
leukocyte count
1
1
1
71
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
93.1
myeloid white cell count
1
78.5
monocyte count
1
74.8
platelet crit
2
71.2
leukocyte count
1
71
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine incorporator 1
VGNC:3700
462975
Macaque
serine incorporator 1
713999
Mouse
MGI:1926228
56442
Rat
RGD:727843
294421
Dog
serine incorporator 1
VGNC:46019
476277
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine incorporator 1
Macaque
serine incorporator 1
Mouse
Rat
Dog
serine incorporator 1
Publication Statistics
PubMed Score 28.60
PubMed score by year
PubTator Score 48.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title