Tbio SEPT8 Septin-8

Protein Summary

Description

Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). Isoform 4: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q92599
• A6NC65
• A6NKP6
• F6W7K9
• Q8IX36
• Q8IX37
• Q9BVB3

Gene Name

• SEPT8

Ensembl ID

• ENST00000296873
• ENSP00000296873
• ENSG00000164402
• ENST00000378699
• ENSP00000367971
• ENST00000378719
• ENSP00000367991
• ENST00000448933
• ENSP00000399840
• ENST00000458488
• ENSP00000394766

Symbol

• KIAA0202
• SEP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.76
transcription factor perturbation	0.74
histone modification site profile	0.69
cell line	0.66
interacting protein	0.63

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Septin-8

Protein / Cytoskeletal Protein / Septin-8

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Septin-8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.69   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 207   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.69   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (54)

Explore Interacting Targets

1 – 10 of 54

• See Interactions on String-DB

SEPT7

Tbio

Novelty:  0.00554708

p_int:  0.999999894

p_ni:  1.06e-7

Score:  0.968

Data Source:  BioPlex,STRINGDB

SEPT3

Tbio

Novelty:  0.008513

p_int:  0.999999212

p_ni:  7.88e-7

Score:  0.856

Data Source:  BioPlex,STRINGDB

SEPT1

Tdark

Novelty:  0.04450119

p_int:  0.99999846

p_ni:  0.00000154

Score:  0.938

Data Source:  BioPlex,STRINGDB

SEPT12

Tbio

Novelty:  0.06228277

p_int:  0.999996276

p_ni:  0.000003724

Score:  0.879

Data Source:  BioPlex,STRINGDB

SEPT2

Tbio

Novelty:  0.01047916

p_int:  0.999968819

p_ni:  0.000031181

Score:  0.971

Data Source:  BioPlex,STRINGDB

CDC42EP4

Tdark

Novelty:  0.27965905

p_int:  0.999966481

p_ni:  0.000033519

Score:  0.866

Data Source:  BioPlex,STRINGDB

SEPT6

Tbio

Novelty:  0.00885503

p_int:  0.999950078

p_ni:  0.000049922

Score:  0.866

Data Source:  BioPlex,STRINGDB

MRPL12

Tbio

Novelty:  0.10646542

p_int:  0.999931076

p_ni:  0.000068924

Score:  0.516

Data Source:  BioPlex,STRINGDB

SEPT10

Tbio

Novelty:  0.14834834

p_int:  0.999917871

p_ni:  0.000082129

Score:  0.92

Data Source:  BioPlex,STRINGDB

ACAP3

Tbio

Novelty:  0.19558023

p_int:  0.999779841

p_ni:  0.000220159

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Bacterial invasion of epithelial cells	73 targets	path:hsa05100

Name	Explore in Pharos	Explore in Source
Bacterial invasion of epithelial cells	73 targets	path:hsa05100

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (3)

Components (5)

Processes (6)

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1 – 3 of 3

GO Term	Evidence	Assigned by
GTPase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein-containing complex scaffold activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
GTP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (28)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 28

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
asthma	EFO_0000270	6	8	0	1.1	97.2
atopic eczema	EFO_0000274	5	6	0	1.1	94.3
allergy	EFO_0003785	5	5	2	1.1	92.7
childhood onset asthma	EFO_0004591	3	3	0	1.2	89.7
neutrophil percentage of granulocytes	EFO_0007994	1	1	1		84.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 28

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
asthma	EFO_0000270	0	1.1	97.2
atopic eczema	EFO_0000274	0	1.1	94.3
allergy	EFO_0003785	2	1.1	92.7
childhood onset asthma	EFO_0004591	0	1.2	89.7
neutrophil percentage of granulocytes	EFO_0007994	1		84.9

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Cell junction
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
GTP-binding

GWAS Trait Find Similar Targets

No Header	No Header
age at onset
alcohol consumption measurement
allergic rhinitis
allergy
alopecia areata
asthma
atopic eczema
atopic march
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
growth/size/body region phenotype
hematopoietic system phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	septin 8	VGNC:4156	107974857
Macaque	septin 8		708424
Mouse	septin 8	MGI:894310	20362
Rat	septin 8	RGD:1308449	303135
Horse	septin 8	VGNC:22835	100063132

Species	Name	OMA	EggNOG	Inparanoid
Chimp	septin 8
Macaque	septin 8
Mouse	septin 8
Rat	septin 8
Horse	septin 8

Publication Statistics

PubMed Score 69.69

PubMed score by year

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PubTator Score 16.43

PubTator score by year

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Related Publications

Text Mined References (23)

GeneRif Annotations (8)

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10

0 of 0

PMID	Year	Title