Protein Summary
Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). Isoform 4: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
- ENST00000296873
- ENSP00000296873
- ENSG00000164402
- ENST00000378699
- ENSP00000367971
- ENST00000378719
- ENSP00000367991
- ENST00000448933
- ENSP00000399840
- ENST00000458488
- ENSP00000394766
- KIAA0202
- SEP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.76 | ||
transcription factor perturbation | 0.74 | ||
histone modification site profile | 0.69 | ||
cell line | 0.66 | ||
interacting protein | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.69 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 207 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.69 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 207 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (54)
SEPT7
Novelty: 0.00554708
p_int: 0.999999894
p_ni: 1.06e-7
Score: 0.968
Data Source: BioPlex,STRINGDB
SEPT3
Novelty: 0.008513
p_int: 0.999999212
p_ni: 7.88e-7
Score: 0.856
Data Source: BioPlex,STRINGDB
SEPT1
Novelty: 0.04450119
p_int: 0.99999846
p_ni: 0.00000154
Score: 0.938
Data Source: BioPlex,STRINGDB
SEPT12
Novelty: 0.06228277
p_int: 0.999996276
p_ni: 0.000003724
Score: 0.879
Data Source: BioPlex,STRINGDB
SEPT2
Novelty: 0.01047916
p_int: 0.999968819
p_ni: 0.000031181
Score: 0.971
Data Source: BioPlex,STRINGDB
CDC42EP4
Novelty: 0.27965905
p_int: 0.999966481
p_ni: 0.000033519
Score: 0.866
Data Source: BioPlex,STRINGDB
SEPT6
Novelty: 0.00885503
p_int: 0.999950078
p_ni: 0.000049922
Score: 0.866
Data Source: BioPlex,STRINGDB
MRPL12
Novelty: 0.10646542
p_int: 0.999931076
p_ni: 0.000068924
Score: 0.516
Data Source: BioPlex,STRINGDB
SEPT10
Novelty: 0.14834834
p_int: 0.999917871
p_ni: 0.000082129
Score: 0.92
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Bacterial invasion of epithelial cells | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Bacterial invasion of epithelial cells | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
6 | 8 | 0 | 1.1 | 97.2 | |||||
5 | 6 | 0 | 1.1 | 94.3 | |||||
5 | 5 | 2 | 1.1 | 92.7 | |||||
childhood onset asthma | 3 | 3 | 0 | 1.2 | 89.7 | ||||
neutrophil percentage of granulocytes | 1 | 1 | 1 | 84.9 | |||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.1 | 97.2 | |||||
0 | 1.1 | 94.3 | |||||
2 | 1.1 | 92.7 | |||||
childhood onset asthma | 0 | 1.2 | 89.7 | ||||
neutrophil percentage of granulocytes | 1 | 84.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | septin 8 | VGNC:4156 | 107974857 | |||||
Macaque | septin 8 | 708424 | ||||||
Mouse | MGI:894310 | 20362 | ||||||
Rat | RGD:1308449 | 303135 | ||||||
Horse | septin 8 | VGNC:22835 | 100063132 | |||||
Publication Statistics
PubMed Score 69.69
PubMed score by year
PubTator Score 16.43
PubTator score by year
Related Publications
Text Mined References (23)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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