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Tbio
SEPT8
Septin-8

Protein Summary
Description
Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). Isoform 4: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296873
  • ENSP00000296873
  • ENSG00000164402
  • ENST00000378699
  • ENSP00000367971
  • ENST00000378719
  • ENSP00000367991
  • ENST00000448933
  • ENSP00000399840
  • ENST00000458488
  • ENSP00000394766

Symbol
  • KIAA0202
  • SEP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
transcription factor perturbation
0.74
histone modification site profile
0.69
cell line
0.66
interacting protein
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.69   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.69   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
SEPT7
Tbio
Novelty:  0.00554708
p_int:  0.999999894
p_ni:  1.06e-7
Score:  0.968
Data Source:  BioPlex,STRINGDB
SEPT3
Tbio
Novelty:  0.008513
p_int:  0.999999212
p_ni:  7.88e-7
Score:  0.856
Data Source:  BioPlex,STRINGDB
SEPT1
Tdark
Novelty:  0.04450119
p_int:  0.99999846
p_ni:  0.00000154
Score:  0.938
Data Source:  BioPlex,STRINGDB
SEPT12
Tbio
Novelty:  0.06228277
p_int:  0.999996276
p_ni:  0.000003724
Score:  0.879
Data Source:  BioPlex,STRINGDB
SEPT2
Tbio
Novelty:  0.01047916
p_int:  0.999968819
p_ni:  0.000031181
Score:  0.971
Data Source:  BioPlex,STRINGDB
CDC42EP4
Tdark
Novelty:  0.27965905
p_int:  0.999966481
p_ni:  0.000033519
Score:  0.866
Data Source:  BioPlex,STRINGDB
SEPT6
Tbio
Novelty:  0.00885503
p_int:  0.999950078
p_ni:  0.000049922
Score:  0.866
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.999931076
p_ni:  0.000068924
Score:  0.516
Data Source:  BioPlex,STRINGDB
SEPT10
Tbio
Novelty:  0.14834834
p_int:  0.999917871
p_ni:  0.000082129
Score:  0.92
Data Source:  BioPlex,STRINGDB
ACAP3
Tbio
Novelty:  0.19558023
p_int:  0.999779841
p_ni:  0.000220159
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
8
0
1.1
97.2
5
6
0
1.1
94.3
5
5
2
1.1
92.7
childhood onset asthma
3
3
0
1.2
89.7
neutrophil percentage of granulocytes
1
1
1
84.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
97.2
0
1.1
94.3
2
1.1
92.7
childhood onset asthma
0
1.2
89.7
neutrophil percentage of granulocytes
1
84.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
septin 8
VGNC:4156
107974857
Macaque
septin 8
708424
Mouse
MGI:894310
20362
Rat
RGD:1308449
303135
Horse
septin 8
VGNC:22835
100063132
Species
Name
OMA
EggNOG
Inparanoid
Chimp
septin 8
Macaque
septin 8
Mouse
Rat
Horse
septin 8
Publication Statistics
PubMed Score 69.69
PubMed score by year
PubTator Score 16.43
PubTator score by year
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Related Publications
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PMID
Year
Title