Tbio SEPT6 Septin-6

Protein Summary

Description

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14141
• Q5JTK0
• Q969W5
• Q96A13
• Q96GR1
• Q96P86
• Q96P87

Gene Name

• SEPT6

Ensembl ID

• ENST00000343984
• ENSP00000341524
• ENSG00000125354
• ENST00000354228
• ENSP00000346169
• ENST00000360156
• ENSP00000353278
• ENST00000394610
• ENSP00000378108
• ENST00000460411
• ENSP00000435818
• ENST00000489216
• ENSP00000418715

Symbol

• KIAA0128
• SEP2
• SEP2
• SEPT2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
kinase perturbation	0.95
disease perturbation	0.9
cellular component	0.86
molecular function	0.76

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Septin-6

Protein / Cytoskeletal Protein / Septin-6

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Septin-6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.34   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 264   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.34   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0