Protein Summary
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
- ENST00000343984
- ENSP00000341524
- ENSG00000125354
- ENST00000354228
- ENSP00000346169
- ENST00000360156
- ENSP00000353278
- ENST00000394610
- ENSP00000378108
- ENST00000460411
- ENSP00000435818
- ENST00000489216
- ENSP00000418715
- KIAA0128
- SEP2
- SEP2
- SEPT2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
kinase perturbation | 0.95 | ||
disease perturbation | 0.9 | ||
cellular component | 0.86 | ||
molecular function | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 126.22 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 264 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 126.22 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 264 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (61)
SEPT2
Novelty: 0.01047916
p_int: 0.999999999
p_ni: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
SEPT7
Novelty: 0.00554708
p_int: 0.999999999
p_ni: 1e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
SEPT10
Novelty: 0.14834834
p_int: 0.999999971
p_ni: 2.9e-8
Score: 0.866
Data Source: BioPlex,STRINGDB
SEPT5
Novelty: 0.01670991
p_int: 0.999999796
p_ni: 2.04e-7
Score: 0.965
Data Source: BioPlex,STRINGDB
SEPT4
Novelty: 0.0037115
p_int: 0.999992139
p_ni: 0.000007861
Score: 0.995
Data Source: BioPlex,STRINGDB
SEPT14
Novelty: 0.07155096
p_int: 0.999959929
p_ni: 2.41e-7
p_wrong: 0.000039829
Score: 0.858
Data Source: BioPlex,STRINGDB
SEPT9
Novelty: 0.00407266
p_int: 0.999952978
p_ni: 0.000047022
Score: 0.962
Data Source: BioPlex,STRINGDB
SEPT8
Novelty: 0.01431499
p_int: 0.999950078
p_ni: 0.000049922
Score: 0.866
Data Source: BioPlex,STRINGDB
TRIM32
Family: Enzyme
Novelty: 0.00103526
p_int: 0.999820973
p_ni: 0.000179027
Data Source: BioPlex
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Bacterial invasion of epithelial cells | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Bacterial invasion of epithelial cells | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (3)
Components (12)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 1 | 1 | 1 | 33.1 | |||||
reticulocyte count | 1 | 1 | 1 | 31.4 | |||||
reticulocyte measurement | 1 | 1 | 1 | 28.1 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 1 | 33.1 | |||||
reticulocyte count | 1 | 31.4 | |||||
reticulocyte measurement | 1 | 28.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | septin 6 | 694021 | ||||||
Mouse | MGI:1888939 | 56526 | ||||||
Rat | RGD:1585082 | 691335 | ||||||
Dog | septin 6 | VGNC:46015 | 612892 | |||||
Horse | septin 6 | VGNC:22833 | 100058639 | |||||
Publication Statistics
PubMed Score 126.22
PubMed score by year
PubTator Score 80.44
PubTator score by year
Related Publications
Text Mined References (38)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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