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Tbio
SEPT2
Septin-2

Protein Summary
Description
Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of tr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360051
  • ENSP00000353157
  • ENSG00000168385
  • ENST00000391971
  • ENSP00000375832
  • ENST00000391973
  • ENSP00000375834
  • ENST00000401990
  • ENSP00000385109
  • ENST00000402092
  • ENSP00000385172
  • ENST00000616972
  • ENSP00000479861

Symbol
  • DIFF6
  • KIAA0158
  • NEDD5
  • DIFF6
  • NEDD5
  • NEDD-5
  • Pnutl3
  • hNedd5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
virus perturbation
1
disease perturbation
0.9
molecular function
0.86
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.56   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 400   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.56   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (188)
SEPT3
Tbio
Novelty:  0.008513
p_int:  1
Score:  0.914
Data Source:  BioPlex,STRINGDB
SEPT6
Tbio
Novelty:  0.00885503
p_int:  0.999999999
p_ni:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
SEPT7
Tbio
Novelty:  0.00554708
p_int:  0.999999998
p_ni:  2e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
SEPT10
Tbio
Novelty:  0.14834834
p_int:  0.999999976
p_ni:  2.4e-8
Score:  0.932
Data Source:  BioPlex,STRINGDB
SEPT12
Tbio
Novelty:  0.06228277
p_int:  0.999998735
p_ni:  0.000001265
Score:  0.992
Data Source:  BioPlex,STRINGDB
SEPT5
Tbio
Novelty:  0.01670991
p_int:  0.999987613
p_ni:  0.000012387
Score:  0.905
Data Source:  BioPlex,STRINGDB
SEPT8
Tbio
Novelty:  0.01431499
p_int:  0.999968819
p_ni:  0.000031181
Score:  0.971
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.99993147
p_ni:  0.00006853
Score:  0.513
Data Source:  BioPlex,STRINGDB
SEPT9
Tchem
Novelty:  0.00407266
p_int:  0.999917845
p_ni:  0.000082153
p_wrong:  1e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
SEPT1
Tdark
Novelty:  0.04450119
p_int:  0.999913847
p_ni:  0.000086153
Score:  0.871
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
2
2
85
fibrinogen measurement
4
2
4
82.6
apolipoprotein A 1 measurement
2
2
2
79.4
alkaline phosphatase measurement
2
2
1
6.3
77
3
2
0
1.1
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
85
fibrinogen measurement
4
82.6
apolipoprotein A 1 measurement
2
79.4
alkaline phosphatase measurement
1
6.3
77
0
1.1
74
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
septin 2
VGNC:2812
460082
Macaque
septin 2
717682
Mouse
MGI:97298
18000
Rat
RGD:620056
117515
Dog
septin 2
VGNC:46014
487886
Species
Name
OMA
EggNOG
Inparanoid
Chimp
septin 2
Macaque
septin 2
Mouse
Rat
Dog
septin 2
Publication Statistics
PubMed Score 98.56
PubMed score by year
PubTator Score 67.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title