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Tbio
SEPT2
Septin-2

Protein Summary
Description
Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of tr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360051
  • ENSP00000353157
  • ENSG00000168385
  • ENST00000391971
  • ENSP00000375832
  • ENST00000391973
  • ENSP00000375834
  • ENST00000401990
  • ENSP00000385109
  • ENST00000402092
  • ENSP00000385172
  • ENST00000616972
  • ENSP00000479861

Symbol
  • DIFF6
  • KIAA0158
  • NEDD5
  • DIFF6
  • NEDD5
  • NEDD-5
  • Pnutl3
  • hNedd5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
virus perturbation
1
disease perturbation
0.9
molecular function
0.86
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 970.17   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 400   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 970.17   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0