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Tbio
SEPT14
Septin-14

Protein Summary
Description
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). SEPT14 is a member of the highly conserved septin family of GTP-binding cytoskeletal proteins implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis, and other cellular functions (Peterson et al., 2007 [PubMed 17922164]).[supplied by OMIM, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388975
  • ENSP00000373627
  • ENSG00000154997
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
interacting protein
0.71
microRNA
0.59
cell type or tissue
0.52
tissue
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.25   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.25   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
SEPT3
Tbio
Novelty:  0.008513
p_int:  0.999985685
p_ni:  3e-9
p_wrong:  0.000014312
Score:  0.835
Data Source:  BioPlex,STRINGDB
SEPT6
Tbio
Novelty:  0.00885503
p_int:  0.999959929
p_ni:  2.41e-7
p_wrong:  0.000039829
Score:  0.858
Data Source:  BioPlex,STRINGDB
SEPT10
Tbio
Novelty:  0.14834834
p_int:  0.999953073
p_ni:  3e-9
p_wrong:  0.000046923
Score:  0.867
Data Source:  BioPlex,STRINGDB
SEPT7
Tbio
Novelty:  0.00554708
p_int:  0.999867315
p_wrong:  0.000132685
Score:  0.9
Data Source:  BioPlex,STRINGDB
CDC42EP4
Tdark
Novelty:  0.27965905
p_int:  0.912983598
p_ni:  4.04e-7
p_wrong:  0.087015998
Score:  0.849
Data Source:  BioPlex,STRINGDB
ZNF713
Tdark
Family:  TF
Novelty:  0.53817745
Score:  0.634
Data Source:  STRINGDB
VSTM2A
Tbio
Novelty:  0.34891628
Score:  0.605
Data Source:  STRINGDB
PSPH
Tbio
Family:  Enzyme
Novelty:  0.01078634
Score:  0.584
Data Source:  STRINGDB
LANCL2
Tchem
Novelty:  0.06086418
Score:  0.581
Data Source:  STRINGDB
SEPT1
Tdark
Novelty:  0.04450119
Score:  0.576
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
2
5
8
91.3
body height
1
1
1
67.3
metabolite measurement
1
1
1
45.7
2
2
1
1
38.8
serum alanine aminotransferase measurement
1
1
1
4.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
8
91.3
body height
1
67.3
metabolite measurement
1
45.7
1
1
38.8
serum alanine aminotransferase measurement
1
4.4
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
septin 14
VGNC:4504
463416
Mouse
MGI:1921472
74222
Rat
RGD:1596186
689118
Dog
septin 14
483382
Horse
septin 14
VGNC:22831
100061054
Species
Name
OMA
EggNOG
Inparanoid
Chimp
septin 14
Mouse
Rat
Dog
septin 14
Horse
septin 14
Publication Statistics
PubMed Score 14.25
PubMed score by year
PubTator Score 14.10
PubTator score by year
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Related Publications
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PMID
Year
Title