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Tbio
SEPT12
Septin-12

Protein Summary
Description
Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (PubMed:24213608). Forms a filamentous structure with SEPT7, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). May play a role in cytokinesis (Potential). This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268231
  • ENSP00000268231
  • ENSG00000140623
  • ENST00000396693
  • ENSP00000379922

Symbol
  • SPGF10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
cellular component
0.78
virus perturbation
0.55
gene perturbation
0.5
cell type or tissue
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.15   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.15   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
SEPT5
Tbio
Novelty:  0.01670991
p_int:  0.999999312
p_ni:  6.88e-7
Score:  0.928
Data Source:  BioPlex,STRINGDB
SEPT2
Tbio
Novelty:  0.01047916
p_int:  0.999998735
p_ni:  0.000001265
Score:  0.992
Data Source:  BioPlex,STRINGDB
SEPT10
Tbio
Novelty:  0.14834834
p_int:  0.999998596
p_ni:  0.000001403
p_wrong:  1e-9
Score:  0.89
Data Source:  BioPlex,STRINGDB
SEPT8
Tbio
Novelty:  0.01431499
p_int:  0.999996276
p_ni:  0.000003724
Score:  0.879
Data Source:  BioPlex,STRINGDB
SEPT4
Tbio
Novelty:  0.0037115
p_int:  0.999988679
p_ni:  0.000011321
Score:  0.992
Data Source:  BioPlex,STRINGDB
PDS5B
Tbio
Novelty:  0.00295057
p_int:  0.999935776
p_ni:  0.000064224
Score:  0.187
Data Source:  BioPlex,STRINGDB
SEPT6
Tbio
Novelty:  0.00885503
p_int:  0.99952929
p_ni:  0.00047071
Score:  0.987
Data Source:  BioPlex,STRINGDB
SEPT11
Tbio
Novelty:  0.05272429
p_int:  0.99929215
p_ni:  0.00070785
Score:  0.874
Data Source:  BioPlex,STRINGDB
SEPT7
Tbio
Novelty:  0.00554708
p_int:  0.99925379
p_ni:  0.00074621
Score:  0.992
Data Source:  BioPlex,STRINGDB
SEPT3
Tbio
Novelty:  0.008513
p_int:  0.995676362
p_ni:  0.004323638
Score:  0.847
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
72.8
mean platelet volume
1
1
1
58.4
waist-hip ratio
1
1
1
35
high density lipoprotein cholesterol measurement
1
1
1
33.1
ferritin measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
72.8
mean platelet volume
1
58.4
waist-hip ratio
1
35
high density lipoprotein cholesterol measurement
1
33.1
ferritin measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
septin 12
VGNC:5915
748303
Mouse
MGI:1918339
71089
Rat
RGD:1565511
363542
Dog
septin 12
VGNC:46013
100688231
Horse
septin 12
VGNC:22830
100069881
Species
Name
OMA
EggNOG
Inparanoid
Chimp
septin 12
Mouse
Rat
Dog
septin 12
Horse
septin 12
Publication Statistics
PubMed Score 22.15
PubMed score by year
PubTator Score 16.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title