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Tbio
SEPT11
Septin-11

Protein Summary
Description
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).[supplied by OMIM, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264893
  • ENSP00000264893
  • ENSG00000138758
  • ENST00000510515
  • ENSP00000422896
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
disease perturbation
0.93
virus perturbation
0.88
kinase perturbation
0.84
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.37   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.37   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
SEPT7
Tbio
Novelty:  0.00554708
p_int:  0.999993521
p_ni:  0.000006479
Score:  0.99
Data Source:  BioPlex,STRINGDB
SEPT1
Tdark
Novelty:  0.04450119
p_int:  0.999938354
p_ni:  0.000061646
Score:  0.934
Data Source:  BioPlex,STRINGDB
SEPT3
Tbio
Novelty:  0.008513
p_int:  0.999805841
p_ni:  0.000194159
Score:  0.882
Data Source:  BioPlex,STRINGDB
SEPT6
Tbio
Novelty:  0.00885503
p_int:  0.99950275
p_ni:  0.00049725
Score:  0.866
Data Source:  BioPlex,STRINGDB
SEPT12
Tbio
Novelty:  0.06228277
p_int:  0.99929215
p_ni:  0.00070785
Score:  0.874
Data Source:  BioPlex,STRINGDB
SEPT2
Tbio
Novelty:  0.01047916
p_int:  0.999051811
p_ni:  0.000948189
Score:  0.992
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.9981284
p_ni:  0.0018716
Score:  0.368
Data Source:  BioPlex,STRINGDB
CDC42EP4
Tbio
Novelty:  0.27965905
p_int:  0.997501813
p_ni:  0.002498187
Score:  0.896
Data Source:  BioPlex,STRINGDB
SEPT10
Tbio
Novelty:  0.14834834
p_int:  0.992787037
p_ni:  0.007212963
Score:  0.861
Data Source:  BioPlex,STRINGDB
ACAP3
Tbio
Novelty:  0.19558023
p_int:  0.989638965
p_ni:  0.010361035
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
86.8
emphysema pattern measurement
1
1
1
9.9
educational attainment
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
86.8
emphysema pattern measurement
1
9.9
educational attainment
1
6.1
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
septin 11
VGNC:739
461233
Macaque
septin 11
698867
Mouse
MGI:1277214
52398
Rat
RGD:1307405
305227
Dog
septin 11
VGNC:46012
478439
Species
Name
OMA
EggNOG
Inparanoid
Chimp
septin 11
Macaque
septin 11
Mouse
Rat
Dog
septin 11
Publication Statistics
PubMed Score 19.37
PubMed score by year
PubTator Score 59.99
PubTator score by year
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Related Publications
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PMID
Year
Title