You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SEPT10
Septin-10

Protein Summary
Description
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. A pseudogene for this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397712
  • ENSP00000380824
  • ENSG00000186522
  • ENST00000397714
  • ENSP00000380826
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
histone modification site profile
0.81
molecular function
0.76
protein complex
0.71
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.21   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.21   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
SEPT7
Tbio
Novelty:  0.00554708
p_int:  1
Score:  0.925
Data Source:  BioPlex,STRINGDB
SEPT3
Tbio
Novelty:  0.008513
p_int:  1
Score:  0.846
Data Source:  BioPlex,STRINGDB
SEPT2
Tbio
Novelty:  0.01047916
p_int:  0.999999976
p_ni:  2.4e-8
Score:  0.932
Data Source:  BioPlex,STRINGDB
SEPT6
Tbio
Novelty:  0.00885503
p_int:  0.999999971
p_ni:  2.9e-8
Score:  0.866
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.999999543
p_ni:  4.57e-7
Score:  0.309
Data Source:  BioPlex,STRINGDB
CDC42EP4
Tdark
Novelty:  0.27965905
p_int:  0.99999898
p_ni:  0.00000102
Score:  0.876
Data Source:  BioPlex,STRINGDB
SEPT12
Tbio
Novelty:  0.06228277
p_int:  0.999998596
p_ni:  0.000001403
p_wrong:  1e-9
Score:  0.89
Data Source:  BioPlex,STRINGDB
SEPT1
Tdark
Novelty:  0.04450119
p_int:  0.999997168
p_ni:  0.000002832
p_wrong:  1e-9
Score:  0.937
Data Source:  BioPlex,STRINGDB
SEPT14
Tbio
Novelty:  0.07155096
p_int:  0.999953073
p_ni:  3e-9
p_wrong:  0.000046923
Score:  0.867
Data Source:  BioPlex,STRINGDB
SEPT8
Tbio
Novelty:  0.01431499
p_int:  0.999917871
p_ni:  0.000082129
Score:  0.92
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
soluble triggering receptor expressed on myeloid cells 2 measurement
1
1
0
5379.1
24.5
red blood cell density measurement
1
1
1
11.3
platelet count
1
1
1
10.2
platelet crit
1
1
1
10.2
1
1
0
1.1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
soluble triggering receptor expressed on myeloid cells 2 measurement
0
5379.1
24.5
red blood cell density measurement
1
11.3
platelet count
1
10.2
platelet crit
1
10.2
0
1.1
0.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
septin 10
695515
Mouse
MGI:1918110
103080
Rat
RGD:1359307
309891
Dog
septin 10
VGNC:46011
100688206
Horse
septin 10
VGNC:22828
100060477
Species
Name
OMA
EggNOG
Inparanoid
Macaque
septin 10
Mouse
Rat
Dog
septin 10
Horse
septin 10
Publication Statistics
PubMed Score 5.21
PubMed score by year
PubTator Score 15.38
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title