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Tdark
SEPT1
Septin-1

Protein Summary
Description
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000571393
  • ENSP00000460441
  • ENSG00000180096

Symbol
  • DIFF6
  • PNUTL3
  • LARP
  • SEP1
  • DIFF6
  • PNUTL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.79
molecular function
0.76
disease
0.65
tissue
0.59
tissue sample
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.64   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.64   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
SEPT5
Tbio
Novelty:  0.01670991
p_int:  1
Score:  0.87
Data Source:  BioPlex,STRINGDB
SEPT4
Tbio
Novelty:  0.0037115
p_int:  0.999999997
p_wrong:  3e-9
Score:  0.86
Data Source:  BioPlex,STRINGDB
SEPT3
Tbio
Novelty:  0.008513
p_int:  0.999999825
p_ni:  1.75e-7
Score:  0.919
Data Source:  BioPlex,STRINGDB
SEPT8
Tbio
Novelty:  0.01431499
p_int:  0.99999846
p_ni:  0.00000154
Score:  0.938
Data Source:  BioPlex,STRINGDB
SEPT10
Tbio
Novelty:  0.14834834
p_int:  0.999997168
p_ni:  0.000002832
p_wrong:  1e-9
Score:  0.937
Data Source:  BioPlex,STRINGDB
SEPT9
Tchem
Novelty:  0.00407266
p_int:  0.99995235
p_ni:  0.00004765
Score:  0.933
Data Source:  BioPlex,STRINGDB
SEPT11
Tbio
Novelty:  0.05272429
p_int:  0.999938354
p_ni:  0.000061646
Score:  0.934
Data Source:  BioPlex,STRINGDB
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.999937224
p_ni:  0.000062767
p_wrong:  8e-9
Score:  0.224
Data Source:  BioPlex,STRINGDB
SEPT2
Tbio
Novelty:  0.01047916
p_int:  0.999913847
p_ni:  0.000086153
Score:  0.871
Data Source:  BioPlex,STRINGDB
SEPT7
Tbio
Novelty:  0.00554708
p_int:  0.999864179
p_ni:  0.00013582
Score:  0.865
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
2
2
94.8
lymphocyte count
3
2
3
91.1
leukocyte count
2
2
2
90
lymphocyte percentage of leukocytes
2
2
2
85.7
neutrophil count
2
2
2
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
94.8
lymphocyte count
3
91.1
leukocyte count
2
90
lymphocyte percentage of leukocytes
2
85.7
neutrophil count
2
82.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
septin 1
710226
Mouse
MGI:1858916
54204
Rat
RGD:1307216
293507
Dog
septin 1
VGNC:46010
489900
Horse
septin 1
VGNC:51235
100065662
Species
Name
OMA
EggNOG
Inparanoid
Macaque
septin 1
Mouse
Rat
Dog
septin 1
Horse
septin 1
Publication Statistics
PubMed Score 19.64
PubMed score by year
PubTator Score 168.94
PubTator score by year
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Related Publications
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PMID
Year
Title