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Tdark
SEPHS2
Selenide, water dikinase 2

Protein Summary
Description
Synthesizes selenophosphate from selenide and ATP. This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000478753
  • ENSP00000418669
  • ENSG00000179918

Symbol
  • SPS2
  • SPS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor binding site profile
0.92
disease perturbation
0.9
molecular function
0.88
transcription factor perturbation
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.42   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.42   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
CCL22
Tbio
Novelty:  0.00245992
p_int:  0.999997706
p_ni:  0.000002081
p_wrong:  2.13e-7
Data Source:  BioPlex
ENDOV
Tbio
Family:  Enzyme
Novelty:  0.00459706
p_int:  0.999997502
p_ni:  0.000002406
p_wrong:  9.2e-8
Score:  0.332
Data Source:  BioPlex,STRINGDB
TNNC2
Tbio
Novelty:  0.07759506
p_int:  0.999994691
p_ni:  0.000005305
p_wrong:  3e-9
Data Source:  BioPlex
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.999985569
p_ni:  0.000014333
p_wrong:  9.9e-8
Data Source:  BioPlex
CDPF1
Tdark
Novelty:  0.85714286
p_int:  0.999698952
p_ni:  0.000152898
p_wrong:  0.000148151
Data Source:  BioPlex
FAM86C1
Tdark
Family:  Enzyme
Novelty:  1.61781609
p_int:  0.998692395
p_ni:  0.000009361
p_wrong:  0.001298245
Data Source:  BioPlex
LOXL4
Tchem
Family:  Enzyme
Novelty:  0.02390071
p_int:  0.998673051
p_ni:  0.000066449
p_wrong:  0.001260499
Score:  0.379
Data Source:  BioPlex,STRINGDB
SEPSECS
Tbio
Family:  Enzyme
Novelty:  0.00698701
Score:  0.989
Data Source:  STRINGDB
TXNRD1
Tclin
Family:  Enzyme
Novelty:  0.00299018
Score:  0.969
Data Source:  STRINGDB
TXNRD2
Tbio
Family:  Enzyme
Novelty:  0.002052
Score:  0.965
Data Source:  STRINGDB
Pathways (9)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Selenoamino acid metabolism
Reactome
Selenocysteine synthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Selenoamino acid metabolism
Selenocysteine synthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
2
2
94.8
lymphocyte count
3
2
3
91.1
leukocyte count
2
2
2
90
lymphocyte percentage of leukocytes
2
2
2
85.7
neutrophil count
2
2
2
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
94.8
lymphocyte count
3
91.1
leukocyte count
2
90
lymphocyte percentage of leukocytes
2
85.7
neutrophil count
2
82.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:108388
20768
Horse
selenophosphate synthetase 2
VGNC:51233
100063822
C. elegans
189912
Fruitfly
FBgn0261270
36587
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
selenophosphate synthetase 2
C. elegans
Fruitfly
Publication Statistics
PubMed Score 57.42
PubMed score by year
PubTator Score 11.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title