Tbio SEPHS1 Selenide, water dikinase 1

Protein Summary

Description

Synthesizes selenophosphate from selenide and ATP. This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• P49903
• B4DWK0
• D3DRS9
• D6PSQ9
• Q5T5U8
• Q5T5U9
• Q9BVT4

Gene Name

• SEPHS1

Ensembl ID

• ENST00000327347
• ENSP00000367893
• ENSG00000086475
• ENST00000378614
• ENSP00000367877
• ENST00000545675
• ENSP00000441119

Symbol

• SELD
• SPS
• SPS1
• SPS
• SELD
• SPS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
kinase perturbation	0.98
molecular function	0.95
transcription factor perturbation	0.94
disease perturbation	0.9

Protein Classes

PANTHER Classes

Protein / Transferase / Selenide, Water Dikinase 1

DTO Classes

Protein / Enzyme / Transferase / Selenide, Water Dikinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.35   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 175   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.35   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0