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Tchem
SENP6
Sentrin-specific protease 6

Protein Summary
Description
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370010
  • ENSP00000359027
  • ENSG00000112701
  • ENST00000447266
  • ENSP00000402527

Symbol
  • KIAA0797
  • SSP1
  • SUSP1
  • SSP1
  • SUSP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
virus perturbation
0.68
tissue sample
0.65
disease perturbation
0.62
histone modification site profile
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.7   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.7   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (80)
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.999999138
p_ni:  8.62e-7
Score:  0.665
Data Source:  BioPlex,STRINGDB
ZDBF2
Tdark
Novelty:  0.19205154
p_int:  0.999486909
p_ni:  0.000513063
p_wrong:  2.8e-8
Score:  0.822
Data Source:  BioPlex,STRINGDB
FHL3
Tbio
Novelty:  0.11505924
p_int:  0.912030894
p_ni:  0.0004369
p_wrong:  0.087532206
Score:  0.222
Data Source:  BioPlex,STRINGDB
SUMO2
Tbio
Novelty:  0.00366833
Score:  0.962
Data Source:  STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.909
Data Source:  STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.909
Data Source:  STRINGDB
NKAIN2
Tbio
Family:  Enzyme
Novelty:  0.07079906
Score:  0.903
Data Source:  STRINGDB
SUMO4
Tbio
Novelty:  0.01534859
Score:  0.895
Data Source:  STRINGDB
SUMO3
Tbio
Novelty:  0.03096465
Score:  0.89
Data Source:  STRINGDB
UBA2
Tbio
Novelty:  0.01582807
Score:  0.857
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein sumoylation.
Name
Explore in Pharos
Explore in Source
Protein modification; protein sumoylation.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
6
7
78.5
BMI-adjusted waist circumference
5
3
5
50.6
1
1
0
1.1
15.8
2
1
0
1.1
11.9
body height
1
1
1
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
7
78.5
BMI-adjusted waist circumference
5
50.6
0
1.1
15.8
0
1.1
11.9
body height
1
11.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SUMO specific peptidase 6
VGNC:12790
462829
Macaque
SUMO1/sentrin specific peptidase 6
716554
Mouse
MGI:1922075
215351
Rat
RGD:1304565
300860
Dog
SUMO1/sentrin specific peptidase 6
481883
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SUMO specific peptidase 6
Macaque
SUMO1/sentrin specific peptidase 6
Mouse
Rat
Dog
SUMO1/sentrin specific peptidase 6
Publication Statistics
PubMed Score 140.70
PubMed score by year
PubTator Score 40.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title