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Tchem
SENP1
Sentrin-specific protease 1

Protein Summary
Description
Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:219656 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000448372
  • ENSP00000394791
  • ENSG00000079387
  • ENST00000549518
  • ENSP00000447328
  • ENST00000549595
  • ENSP00000450076

Symbol
  • SuPr-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor binding site profile
0.9
microRNA
0.86
biological process
0.83
transcription factor
0.67


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.75   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.75   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (113)
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.984873507
p_ni:  0.015126493
Data Source:  BioPlex
ARL11
Tbio
Family:  Enzyme
Novelty:  0.04033783
p_int:  0.971852412
p_ni:  0.028147588
Score:  0.199
Data Source:  BioPlex,STRINGDB
PROZ
Tbio
Family:  Enzyme
Novelty:  0.05629679
p_int:  0.968367328
p_ni:  0.031632672
Data Source:  BioPlex
BLK
Tchem
Family:  Kinase
Novelty:  0.00480349
p_int:  0.920782822
p_ni:  0.075040428
p_wrong:  0.004176751
Score:  0.213
Data Source:  BioPlex,STRINGDB
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
p_int:  0.893826401
p_ni:  0.106173599
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.824654503
p_ni:  0.175345497
Data Source:  BioPlex
LRP1
Tbio
Novelty:  0.00200788
p_int:  0.773557867
p_ni:  0.226442133
Data Source:  BioPlex
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.768300719
p_ni:  0.231699281
Score:  0.184
Data Source:  BioPlex,STRINGDB
TRMT1
Tbio
Family:  Enzyme
Novelty:  0.01795504
p_int:  0.76718643
p_ni:  0.23281357
Score:  0.185
Data Source:  BioPlex,STRINGDB
SIRT6
Tchem
Family:  Epigenetic
Novelty:  0.00155366
p_int:  0.761579135
p_ni:  0.238420865
Score:  0.283
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Processing and activation of SUMO
Reactome
SUMO is proteolytically processed
Reactome
SUMOylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Processing and activation of SUMO
SUMO is proteolytically processed
SUMOylation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
4
12
12
97.7
hemoglobin measurement
3
4
5
97.4
hematocrit
3
3
5
96
red blood cell density measurement
1
1
1
83.1
mean corpuscular volume
1
1
1
73.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
12
97.7
hemoglobin measurement
5
97.4
hematocrit
5
96
red blood cell density measurement
1
83.1
mean corpuscular volume
1
73.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SUMO specific peptidase 1
VGNC:5579
451862
Macaque
SUMO1/sentrin specific peptidase 1
707603
Mouse
MGI:2445054
223870
Rat
RGD:1310275
300193
Dog
SUMO specific peptidase 1
VGNC:46005
477629
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SUMO specific peptidase 1
Macaque
SUMO1/sentrin specific peptidase 1
Mouse
Rat
Dog
SUMO specific peptidase 1
Publication Statistics
PubMed Score 142.75
PubMed score by year
PubTator Score 105.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title