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Tbio
SEMG2
Semenogelin-2

Protein Summary
Description
Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa. The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. An antibacterial activity has been found for a antimicrobial peptide isolated from this protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372769
  • ENSP00000361855
  • ENSG00000124157

Symbol
  • SGII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
tissue
0.45
interacting protein
0.44
biological term
0.42
cell line
0.42


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.89   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.89   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
LSM14B
Tdark
Novelty:  0.31832554
p_int:  0.999999954
p_ni:  4.6e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
TXNDC16
Tdark
Novelty:  0.25365147
p_int:  0.999999887
p_ni:  1.13e-7
Data Source:  BioPlex
DLX6
Tbio
Family:  TF
Novelty:  0.01455012
p_int:  0.999999616
p_ni:  3.84e-7
Data Source:  BioPlex
NUPR1
Tbio
Novelty:  0.00934603
p_int:  0.999999403
p_ni:  5.97e-7
Score:  0.209
Data Source:  BioPlex,STRINGDB
SMURF2
Tchem
Family:  Enzyme
Novelty:  0.00920984
p_int:  0.999998452
p_ni:  0.000001548
Score:  0.183
Data Source:  BioPlex,STRINGDB
SYT16
Tbio
Novelty:  0.05270686
p_int:  0.999994992
p_ni:  0.000005008
Score:  0.183
Data Source:  BioPlex,STRINGDB
MSS51
Tbio
Novelty:  0.06388791
p_int:  0.999994157
p_ni:  0.000005843
Score:  0.209
Data Source:  BioPlex,STRINGDB
FTH1
Tbio
Novelty:  0.000863
p_int:  0.999988841
p_ni:  0.000011159
Data Source:  BioPlex
POLL
Tbio
Family:  Enzyme
Novelty:  0.00244645
p_int:  0.999985073
p_ni:  0.000014927
Score:  0.207
Data Source:  BioPlex,STRINGDB
C9orf139
Tdark
Novelty:  1.54653983
p_int:  0.999980331
p_ni:  0.000019669
Score:  0.187
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
3
3
83.9
elafin measurement
1
1
1
10.5
1
1
0
1.1
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
3
83.9
elafin measurement
1
10.5
0
1.1
5.9
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
semenogelin 2
VGNC:52091
493189
Macaque
semenogelin II
711317
Species
Name
OMA
EggNOG
Inparanoid
Chimp
semenogelin 2
Macaque
semenogelin II
Publication Statistics
PubMed Score 18.89
PubMed score by year
PubTator Score 52.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title