Protein Summary
Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcri ...more
- ENST00000316364
- ENSP00000324857
- ENSG00000137872
- ENST00000354744
- ENSP00000346786
- ENST00000355997
- ENSP00000348276
- ENST00000358066
- ENSP00000350770
- ENST00000389425
- ENSP00000374076
- ENST00000389428
- ENSP00000374079
- ENST00000536845
- ENSP00000446152
- ENST00000558014
- ENSP00000452815
- ENST00000558816
- ENSP00000453661
- KIAA1479
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.97 | ||
microRNA | 0.89 | ||
virus perturbation | 0.83 | ||
protein domain | 0.73 | ||
transcription factor | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.37 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 162 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.37 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 162 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (102)
TPM2
Novelty: 0.00406572
p_int: 0.949452359
p_ni: 0.050544203
p_wrong: 0.000003439
Score: 0.222
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | Other semaphorin interactions | ||||
Reactome | Semaphorin interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
Other semaphorin interactions | ||||
Semaphorin interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (3)
Components (6)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (45)
Items per page:
1 – 5 of 45
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 4 | 4 | 94.5 | |||||
smoking initiation | 3 | 3 | 3 | 85.8 | |||||
self reported educational attainment | 4 | 7 | 7 | 5.6 | 84.7 | ||||
smoking behavior | 1 | 3 | 3 | 79.1 | |||||
3 | 4 | 1 | 5.5 | 74.8 | |||||
Items per page:
1 – 5 of 45
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
smoking status measurement | 4 | 94.5 | |||||
smoking initiation | 3 | 85.8 | |||||
self reported educational attainment | 7 | 5.6 | 84.7 | ||||
smoking behavior | 3 | 79.1 | |||||
1 | 5.5 | 74.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | semaphorin 6D | VGNC:6587 | 467674 | |||||
Macaque | semaphorin 6D | 713885 | ||||||
Mouse | MGI:2387661 | 214968 | ||||||
Rat | RGD:1310910 | 311384 | ||||||
Dog | semaphorin 6D | VGNC:46004 | 100855988 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | semaphorin 6D | |||||
Macaque | semaphorin 6D | |||||
Mouse | ||||||
Rat | ||||||
Dog | semaphorin 6D | |||||
Publication Statistics
PubMed Score 63.37
PubMed score by year
PubTator Score 11.15
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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