Protein Summary
Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcri ...more
- ENST00000316364
- ENSP00000324857
- ENSG00000137872
- ENST00000354744
- ENSP00000346786
- ENST00000355997
- ENSP00000348276
- ENST00000358066
- ENSP00000350770
- ENST00000389425
- ENSP00000374076
- ENST00000389428
- ENSP00000374079
- ENST00000536845
- ENSP00000446152
- ENST00000558014
- ENSP00000452815
- ENST00000558816
- ENSP00000453661
- KIAA1479
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
trait | 0.97 | ||
microRNA | 0.89 | ||
virus perturbation | 0.83 | ||
protein domain | 0.73 | ||
transcription factor | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.12 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 162 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.12 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 162 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0