Protein Summary
May act as positive axonal guidance cues. This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- ENST00000357599
- ENSP00000350215
- ENSG00000082684
- ENST00000451055
- ENSP00000389588
- ENST00000616742
- ENSP00000479602
- KIAA1445
- SEMAG
- SemG
- SEMAG
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
transcription factor binding site profile | 0.74 | ||
histone modification site profile | 0.72 | ||
PubMedID | 0.67 | ||
tissue sample | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.88 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 109 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.88 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 109 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (127)
Nearest Tclin Targets
Pathways (9)
Reactome (8)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Reactome | Diseases of glycosylation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Diseases of glycosylation | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (1)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 3 | 3 | 2 | 2.2 | 96 | ||||
mean platelet volume | 2 | 2 | 2 | 94.3 | |||||
platelet crit | 2 | 1 | 2 | 64.4 | |||||
calcium measurement | 1 | 1 | 1 | 38.8 | |||||
serum albumin measurement | 1 | 1 | 1 | 0.7 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 2 | 2.2 | 96 | ||||
mean platelet volume | 2 | 94.3 | |||||
platelet crit | 2 | 64.4 | |||||
calcium measurement | 1 | 38.8 | |||||
serum albumin measurement | 1 | 0.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | semaphorin 5B | VGNC:7122 | 460636 | |||||
Macaque | semaphorin 5B | 715682 | ||||||
Mouse | MGI:107555 | 20357 | ||||||
Rat | RGD:1308914 | 303901 | ||||||
Dog | semaphorin 5B | VGNC:46000 | 100687386 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | semaphorin 5B | |||||
Macaque | semaphorin 5B | |||||
Mouse | ||||||
Rat | ||||||
Dog | semaphorin 5B | |||||
Publication Statistics
PubMed Score 51.88
PubMed score by year
PubTator Score 11.39
PubTator score by year
Related Publications
Text Mined References (13)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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