Tbio SEMA5B Semaphorin-5B

Protein Summary

Description

May act as positive axonal guidance cues. This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• Q9P283
• A8K5U2
• B7Z393
• F8W9U8
• Q6DD89
• Q6UY12
• Q9NW17

Gene Name

• SEMA5B

Ensembl ID

• ENST00000357599
• ENSP00000350215
• ENSG00000082684
• ENST00000451055
• ENSP00000389588
• ENST00000616742
• ENSP00000479602

Symbol

• KIAA1445
• SEMAG
• SemG
• SEMAG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
transcription factor binding site profile	0.74
histone modification site profile	0.72
PubMedID	0.67
tissue sample	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.54   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.54   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0