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Tbio
SEMA5B
Semaphorin-5B

Protein Summary
Description
May act as positive axonal guidance cues. This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357599
  • ENSP00000350215
  • ENSG00000082684
  • ENST00000451055
  • ENSP00000389588
  • ENST00000616742
  • ENSP00000479602

Symbol
  • KIAA1445
  • SEMAG
  • SemG
  • SEMAG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor binding site profile
0.74
histone modification site profile
0.72
PubMedID
0.67
tissue sample
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.88   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.88   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
PLXNA1
Tbio
Novelty:  0.01195083
Score:  0.943
Data Source:  STRINGDB
PLXNA3
Tbio
Novelty:  0.02016528
Score:  0.943
Data Source:  STRINGDB
PLXND1
Tbio
Novelty:  0.01249713
Score:  0.919
Data Source:  STRINGDB
PLXNC1
Tbio
Novelty:  0.02179837
Score:  0.917
Data Source:  STRINGDB
SPON1
Tbio
Novelty:  0.01071398
Score:  0.916
Data Source:  STRINGDB
THSD7A
Tbio
Novelty:  0.01515873
Score:  0.908
Data Source:  STRINGDB
THBS1
Tchem
Novelty:  0.00073905
Score:  0.907
Data Source:  STRINGDB
THSD7B
Tdark
Novelty:  0.34794254
Score:  0.905
Data Source:  STRINGDB
THBS2
Tbio
Novelty:  0.00310724
Score:  0.905
Data Source:  STRINGDB
ADAMTS9
Tbio
Family:  Enzyme
Novelty:  0.01447959
Score:  0.905
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
3
2
2.2
96
mean platelet volume
2
2
2
94.3
platelet crit
2
1
2
64.4
calcium measurement
1
1
1
38.8
serum albumin measurement
1
1
1
0.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2.2
96
mean platelet volume
2
94.3
platelet crit
2
64.4
calcium measurement
1
38.8
serum albumin measurement
1
0.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
semaphorin 5B
VGNC:7122
460636
Macaque
semaphorin 5B
715682
Mouse
MGI:107555
20357
Rat
RGD:1308914
303901
Dog
semaphorin 5B
VGNC:46000
100687386
Species
Name
OMA
EggNOG
Inparanoid
Chimp
semaphorin 5B
Macaque
semaphorin 5B
Mouse
Rat
Dog
semaphorin 5B
Publication Statistics
PubMed Score 51.88
PubMed score by year
PubTator Score 11.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title