Tbio SEMA4F Semaphorin-4F

Protein Summary

Description

Has growth cone collapse activity against retinal ganglion-cell axons. This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• O95754
• Q542Y7
• Q9NS35

Gene Name

• SEMA4F

Ensembl ID

• ENST00000339773
• ENSP00000342675
• ENSG00000135622
• ENST00000357877
• ENSP00000350547

Symbol

• SEMAM
• SEMAW
• S4F
• SEMAM
• SEMAW
• M-SEMA
• PRO2353
• m-Sema-M

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
disease perturbation	0.9
protein domain	0.85
histone modification site profile	0.79
virus perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Semaphorin-4f

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Semaphorin-4f

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.86   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.86   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (97)

Explore Interacting Targets

1 – 10 of 97

• See Interactions on String-DB

TMPRSS11B

Tdark

Family:  Enzyme

Novelty:  1.20690443

p_int:  0.9981968

p_ni:  0.001803197

p_wrong:  2e-9

Data Source:  BioPlex

PSCA

Tbio

Novelty:  0.00323778

p_int:  0.968264909

p_ni:  0.031704624

p_wrong:  0.000030467

Data Source:  BioPlex

ARSE

Tbio

Family:  Enzyme

Novelty:  0.00151862

p_int:  0.948283399

p_ni:  0.051716474

p_wrong:  1.27e-7

Data Source:  BioPlex

GRIA3

Tclin

Family:  IC

Novelty:  0.00584546

p_int:  0.948245937

p_ni:  0.051754063

Score:  0.177

Data Source:  BioPlex,STRINGDB

CD1E

Tbio

Novelty:  0.00171622

p_int:  0.940853291

p_ni:  0.059146674

p_wrong:  3.5e-8

Data Source:  BioPlex

USO1

Tbio

Novelty:  0.02066669

p_int:  0.922970943

p_ni:  0.077029057

Score:  0.183

Data Source:  BioPlex,STRINGDB

CHRNB4

Tclin

Family:  IC

Novelty:  0.01151716

p_int:  0.856041463

p_ni:  0.143958492

p_wrong:  4.5e-8

Data Source:  BioPlex

P01911

Tchem

Novelty:  0.00240724

p_int:  0.843374394

p_ni:  0.156625606

Score:  0.163

Data Source:  BioPlex,STRINGDB

TMEM30B

Tbio

Novelty:  0.26735006

p_int:  0.839548252

p_ni:  0.160440827

p_wrong:  0.000010921

Data Source:  BioPlex

TMEM106A

Tbio

Novelty:  0.32470607

p_int:  0.804201707

p_ni:  0.195798071

p_wrong:  2.22e-7

Data Source:  BioPlex

Nearest Tclin Targets (2)

Explore Nearest Tclin Targets

Downstream (2)

1 – 2 of 2

ROCK2

Tclin

Family:  Kinase

KEGG Distance:  4

Common Pathways:  1

1: Axon guidance

ROCK1

Tclin

Family:  Kinase

KEGG Distance:  4

Common Pathways:  1

1: Axon guidance

Pathways (1)

KEGG (1)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Axon guidance	180 targets	path:hsa04360

Name	Explore in Pharos	Explore in Source
Axon guidance	180 targets	path:hsa04360

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (3)

Components (6)

Processes (9)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
chemorepellent activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
neuropilin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
semaphorin receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1	1	1		59.9
mean platelet volume	EFO_0004584	2	1	2		31.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1		59.9
mean platelet volume	EFO_0004584	2		31.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Neurogenesis
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
body height
mean platelet volume

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ssemaphorin 4F	VGNC:6657	470411
Macaque	ssemaphorin 4F		710297
Mouse	sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain	MGI:1340055	20355
Rat	ssemaphorin 4F	RGD:3658	29745
Dog	ssemaphorin 4F	VGNC:45997	483098

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ssemaphorin 4F
Macaque	ssemaphorin 4F
Mouse	sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain
Rat	ssemaphorin 4F
Dog	ssemaphorin 4F

Publication Statistics

PubMed Score 133.86

PubMed score by year

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PubTator Score 6.78

PubTator score by year

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Related Publications

Text Mined References (23)

GeneRif Annotations (3)

Items per page:

10

0 of 0

PMID	Year	Title