Tbio SEMA4C Semaphorin-4C

Protein Summary

Description

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.

Uniprot Accession IDs

• Q9C0C4
• Q32MJ3
• Q7Z5X0

Gene Name

• SEMA4C

Ensembl ID

• ENST00000305476
• ENSP00000306844
• ENSG00000168758

Symbol

• KIAA1739
• SEMAI
• SEMAF
• SEMAI
• SEMACL1
• M-SEMA-F

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
transcription factor perturbation	0.8
transcription factor	0.66
transcription factor binding site profile	0.66
PubMedID	0.64

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Semaphorin-4c

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Semaphorin-4c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.34   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 151   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.34   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (155)

Explore Interacting Targets

1 – 10 of 155

• See Interactions on String-DB

NBEAL2

Tbio

Novelty:  0.05579364

p_int:  0.999999873

p_ni:  2e-9

p_wrong:  1.25e-7

Data Source:  BioPlex

NUB1

Tbio

Novelty:  0.00736082

p_int:  0.999995399

p_ni:  0.000003045

p_wrong:  0.000001556

Data Source:  BioPlex

TRIM9

Tbio

Family:  Enzyme

Novelty:  0.06250762

p_int:  0.999974871

p_ni:  0.000024673

p_wrong:  4.55e-7

Data Source:  BioPlex

MSTO1

Tbio

Novelty:  0.05914188

p_int:  0.999907917

p_ni:  0.000092083

p_wrong:  1e-9

Data Source:  BioPlex

HELLS

Tbio

Family:  Enzyme

Novelty:  0.01348077

p_int:  0.999843049

p_ni:  0.000156951

Data Source:  BioPlex

FLCN

Tbio

Novelty:  0.0022007

p_int:  0.999684493

p_ni:  0.000306398

p_wrong:  0.000009109

Data Source:  BioPlex

EXOC6

Tbio

Novelty:  0.01886811

p_int:  0.99965299

p_ni:  0.00034701

Data Source:  BioPlex

IKBKG

Tbio

Family:  Kinase

Novelty:  0.0006149

p_int:  0.999606906

p_ni:  0.000393055

p_wrong:  3.9e-8

Data Source:  BioPlex

SNX5

Tbio

Novelty:  0.04075649

p_int:  0.999601163

p_ni:  0.000398837

Data Source:  BioPlex

LGALS1

Tchem

Novelty:  0.00106509

p_int:  0.999386782

p_ni:  0.000613218

Data Source:  BioPlex

Nearest Tclin Targets (2)

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Downstream (2)

1 – 2 of 2

ROCK1

Tclin

Family:  Kinase

KEGG Distance:  4

Common Pathways:  1

1: Axon guidance

ROCK2

Tclin

Family:  Kinase

KEGG Distance:  4

Common Pathways:  1

1: Axon guidance

Pathways (1)

KEGG (1)

Find Similar Targets

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Axon guidance	180 targets	path:hsa04360

Name	Explore in Pharos	Explore in Source
Axon guidance	180 targets	path:hsa04360

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (3)

Components (6)

Processes (10)

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1 – 3 of 3

GO Term	Evidence	Assigned by
chemorepellent activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
neuropilin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
semaphorin receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (5)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
calcium measurement	EFO_0004838	1	4	4		89.6
mathematical ability	EFO_0004875	3	1	3		53.7
serum non-albumin protein measurement	EFO_0004568	1	1	1		37.6
body height	EFO_0004339	1	1	1		32.7
birth weight	EFO_0004344	1	1	1		31.4

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Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
calcium measurement	EFO_0004838	4		89.6
mathematical ability	EFO_0004875	3		53.7
serum non-albumin protein measurement	EFO_0004568	1		37.6
body height	EFO_0004339	1		32.7
birth weight	EFO_0004344	1		31.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Cell junction
Cell membrane
Complete proteome
Cytoplasmic vesicle
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
birth weight
body height
calcium measurement
mathematical ability
serum non-albumin protein measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
integument phenotype
mortality/aging
nervous system phenotype
pigmentation phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	semaphorin 4C	VGNC:6656	459423
Mouse	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	MGI:109252	20353
Rat	semaphorin 4C	RGD:1562837	301346
Dog	semaphorin 4C	VGNC:45996	481343
Horse	semaphorin 4C	VGNC:51404	100146410

Species	Name	OMA	EggNOG	Inparanoid
Chimp	semaphorin 4C
Mouse	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Rat	semaphorin 4C
Dog	semaphorin 4C
Horse	semaphorin 4C

Publication Statistics

PubMed Score 76.34

PubMed score by year

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PubTator Score 30.92

PubTator score by year

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Related Publications

Text Mined References (20)

GeneRif Annotations (7)

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10

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PMID	Year	Title