Tbio SEMA4C Semaphorin-4C

Protein Summary

Description

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.

Uniprot Accession IDs

• Q9C0C4
• Q32MJ3
• Q7Z5X0

Gene Name

• SEMA4C

Ensembl ID

• ENST00000305476
• ENSP00000306844
• ENSG00000168758

Symbol

• KIAA1739
• SEMAI
• SEMAF
• SEMAI
• SEMACL1
• M-SEMA-F

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
transcription factor perturbation	0.8
transcription factor	0.66
transcription factor binding site profile	0.66
PubMedID	0.64

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Semaphorin-4c

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Semaphorin-4c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.35   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 151   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.35   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0