Protein Summary
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
- ENST00000305476
- ENSP00000306844
- ENSG00000168758
- KIAA1739
- SEMAI
- SEMAF
- SEMAI
- SEMACL1
- M-SEMA-F
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.97 | ||
transcription factor perturbation | 0.8 | ||
transcription factor | 0.66 | ||
transcription factor binding site profile | 0.66 | ||
PubMedID | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.34 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 151 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.34 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 151 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (155)
NUB1
Novelty: 0.00736082
p_int: 0.999995399
p_ni: 0.000003045
p_wrong: 0.000001556
Data Source: BioPlex
TRIM9
Family: Enzyme
Novelty: 0.06250762
p_int: 0.999974871
p_ni: 0.000024673
p_wrong: 4.55e-7
Data Source: BioPlex
MSTO1
Novelty: 0.05914188
p_int: 0.999907917
p_ni: 0.000092083
p_wrong: 1e-9
Data Source: BioPlex
HELLS
Family: Enzyme
Novelty: 0.01348077
p_int: 0.999843049
p_ni: 0.000156951
Data Source: BioPlex
FLCN
Novelty: 0.0022007
p_int: 0.999684493
p_ni: 0.000306398
p_wrong: 0.000009109
Data Source: BioPlex
IKBKG
Family: Kinase
Novelty: 0.0006149
p_int: 0.999606906
p_ni: 0.000393055
p_wrong: 3.9e-8
Data Source: BioPlex
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Axon guidance | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (3)
Components (6)
Processes (10)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
calcium measurement | 1 | 4 | 4 | 89.6 | |||||
mathematical ability | 3 | 1 | 3 | 53.7 | |||||
serum non-albumin protein measurement | 1 | 1 | 1 | 37.6 | |||||
body height | 1 | 1 | 1 | 32.7 | |||||
birth weight | 1 | 1 | 1 | 31.4 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
calcium measurement | 4 | 89.6 | |||||
mathematical ability | 3 | 53.7 | |||||
serum non-albumin protein measurement | 1 | 37.6 | |||||
body height | 1 | 32.7 | |||||
birth weight | 1 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | semaphorin 4C | VGNC:6656 | 459423 | |||||
Mouse | MGI:109252 | 20353 | ||||||
Rat | RGD:1562837 | 301346 | ||||||
Dog | semaphorin 4C | VGNC:45996 | 481343 | |||||
Horse | semaphorin 4C | VGNC:51404 | 100146410 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | semaphorin 4C | |||||
Mouse | ||||||
Rat | ||||||
Dog | semaphorin 4C | |||||
Horse | semaphorin 4C | |||||
Publication Statistics
PubMed Score 76.34
PubMed score by year
PubTator Score 30.92
PubTator score by year
Related Publications
Text Mined References (20)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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