Protein Summary
Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity). This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and sup ...more
- ENST00000355014
- ENSP00000347117
- ENSG00000196189
- ENST00000368282
- ENSP00000357265
- ENST00000368284
- ENSP00000357267
- ENST00000368285
- ENSP00000357268
- SEMAB
- SEMB
- RP35
- SEMB
- SEMAB
- CORD10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.74 | ||
protein domain | 0.73 | ||
transcription factor | 0.71 | ||
disease perturbation | 0.62 | ||
biological process | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 96.65 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 344 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 96.65 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 344 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (137)
TMEM192
Novelty: 0.30699087
p_int: 0.999339649
p_ni: 0.000660339
p_wrong: 1.2e-8
Data Source: BioPlex
LEMD3
Novelty: 0.00579701
p_int: 0.994464836
p_ni: 0.005535161
p_wrong: 3e-9
Data Source: BioPlex
SEMA4C
Novelty: 0.01237067
p_int: 0.993990505
p_ni: 0.006008961
p_wrong: 5.34e-7
Data Source: BioPlex
SIRT5
Family: Epigenetic
Novelty: 0.00225239
p_int: 0.993663319
p_ni: 0.006091591
p_wrong: 0.00024509
Data Source: BioPlex
SEMA4B
Novelty: 0.01387522
p_int: 0.993488178
p_ni: 0.006506451
p_wrong: 0.000005371
Data Source: BioPlex
GMCL1
Novelty: 0.1543762
p_int: 0.981875529
p_ni: 0.000913325
p_wrong: 0.017211146
Data Source: BioPlex
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (6)
Reactome (4)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | Other semaphorin interactions | ||||
Reactome | Semaphorin interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
Other semaphorin interactions | ||||
Semaphorin interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (3)
Components (6)
Processes (11)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mosaic loss of chromosome Y measurement | 3 | 2 | 3 | 94.7 | |||||
serum urea measurement | 1 | 3 | 3 | 84.4 | |||||
HbA1c measurement | 2 | 2 | 2 | 82.4 | |||||
body mass index | 3 | 1 | 3 | 76.3 | |||||
appendicular lean mass | 3 | 2 | 4 | 76.2 | |||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mosaic loss of chromosome Y measurement | 3 | 94.7 | |||||
serum urea measurement | 3 | 84.4 | |||||
HbA1c measurement | 2 | 82.4 | |||||
body mass index | 3 | 76.3 | |||||
appendicular lean mass | 4 | 76.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | semaphorin 4A | VGNC:10993 | 457386 | |||||
Macaque | semaphorin 4A | 718191 | ||||||
Mouse | MGI:107560 | 20351 | ||||||
Rat | RGD:1304636 | 310630 | ||||||
Dog | semaphorin 4A | VGNC:45994 | 490416 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | semaphorin 4A | |||||
Macaque | semaphorin 4A | |||||
Mouse | ||||||
Rat | ||||||
Dog | semaphorin 4A | |||||
Publication Statistics
PubMed Score 96.65
PubMed score by year
PubTator Score 36.85
PubTator score by year
Related Publications
Text Mined References (32)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
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