Tbio SEMA4A Semaphorin-4A

Protein Summary

Description

Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity). This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q9H3S1
• B2RDH8
• B3KR76
• Q5TCI5
• Q5TCJ6
• Q8WUA9

Gene Name

• SEMA4A

Ensembl ID

• ENST00000355014
• ENSP00000347117
• ENSG00000196189
• ENST00000368282
• ENSP00000357265
• ENST00000368284
• ENSP00000357267
• ENST00000368285
• ENSP00000357268

Symbol

• SEMAB
• SEMB
• RP35
• SEMB
• SEMAB
• CORD10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.74
protein domain	0.73
transcription factor	0.71
disease perturbation	0.62
biological process	0.57

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Semaphorin-4a

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Semaphorin-4a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.37   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 344   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.37   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0