Protein Summary
May play a role in cell motility and cell adhesion. This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
- ENST00000002829
- ENSP00000002829
- ENSG00000001617
- ENST00000434342
- ENSP00000409859
- SEMA4
- SEMAK
- SEMA-IV
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
PubMedID | 0.89 | ||
biological process | 0.75 | ||
transcription factor | 0.73 | ||
transcription factor binding site profile | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 150.38 (req: < 5)
Gene RIFs: 38 (req: <= 3)
Antibodies: 184 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 150.38 (req: >= 5)
Gene RIFs: 38 (req: > 3)
Antibodies: 184 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (87)
SEMA3C
Novelty: 0.00828813
p_int: 0.999992792
p_ni: 0.00000174
p_wrong: 0.000005468
Data Source: BioPlex
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Axon guidance | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (3)
Components (3)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (43)
Items per page:
1 – 5 of 43
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 5 | 5 | 4 | 7.2 | 98 | ||||
reticulocyte measurement | 3 | 4 | 7 | 96 | |||||
intelligence | 4 | 13 | 8 | 7 | 94.5 | ||||
body mass index | 2 | 2 | 2 | 91.5 | |||||
heel bone mineral density | 3 | 2 | 3 | 90.4 | |||||
Items per page:
1 – 5 of 43
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 4 | 7.2 | 98 | ||||
reticulocyte measurement | 7 | 96 | |||||
intelligence | 8 | 7 | 94.5 | ||||
body mass index | 2 | 91.5 | |||||
heel bone mineral density | 3 | 90.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | semaphorin 3F | VGNC:7120 | 460387 | |||||
Macaque | semaphorin 3F | 703995 | ||||||
Mouse | MGI:1096347 | 20350 | ||||||
Rat | RGD:1308514 | 315996 | ||||||
Dog | semaphorin 3F | VGNC:45992 | 484763 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | semaphorin 3F | |||||
Macaque | semaphorin 3F | |||||
Mouse | ||||||
Rat | ||||||
Dog | semaphorin 3F | |||||
Publication Statistics
PubMed Score 150.38
PubMed score by year
PubTator Score 67.49
PubTator score by year
Related Publications
Text Mined References (56)
GeneRif Annotations (38)
Items per page:
0 of 0
PMID | Year | Title |
|---|