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Tbio
SEMA3F
Semaphorin-3F

Protein Summary
Description
May play a role in cell motility and cell adhesion. This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000002829
  • ENSP00000002829
  • ENSG00000001617
  • ENST00000434342
  • ENSP00000409859

Symbol
  • SEMA4
  • SEMAK
  • SEMA-IV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
PubMedID
0.89
biological process
0.75
transcription factor
0.73
transcription factor binding site profile
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.38   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.38   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
SEMA3C
Tbio
Novelty:  0.00828813
p_int:  0.999992792
p_ni:  0.00000174
p_wrong:  0.000005468
Data Source:  BioPlex
NRP1
Tchem
Novelty:  0.00153628
Score:  0.981
Data Source:  STRINGDB
PLXNA1
Tbio
Novelty:  0.01195083
Score:  0.968
Data Source:  STRINGDB
PLXNA3
Tbio
Novelty:  0.02016528
Score:  0.965
Data Source:  STRINGDB
NRP2
Tbio
Novelty:  0.00764179
Score:  0.961
Data Source:  STRINGDB
PLXNB1
Tbio
Novelty:  0.01073808
Score:  0.924
Data Source:  STRINGDB
PLXNB3
Tbio
Novelty:  0.02948198
Score:  0.92
Data Source:  STRINGDB
PLXND1
Tbio
Novelty:  0.01249713
Score:  0.92
Data Source:  STRINGDB
PLXNB2
Tbio
Novelty:  0.01925055
Score:  0.92
Data Source:  STRINGDB
PLXNC1
Tbio
Novelty:  0.02179837
Score:  0.915
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
5
5
4
7.2
98
reticulocyte measurement
3
4
7
96
intelligence
4
13
8
7
94.5
body mass index
2
2
2
91.5
heel bone mineral density
3
2
3
90.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
7.2
98
reticulocyte measurement
7
96
intelligence
8
7
94.5
body mass index
2
91.5
heel bone mineral density
3
90.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
semaphorin 3F
VGNC:7120
460387
Macaque
semaphorin 3F
703995
Mouse
MGI:1096347
20350
Rat
RGD:1308514
315996
Dog
semaphorin 3F
VGNC:45992
484763
Species
Name
OMA
EggNOG
Inparanoid
Chimp
semaphorin 3F
Macaque
semaphorin 3F
Mouse
Rat
Dog
semaphorin 3F
Publication Statistics
PubMed Score 150.38
PubMed score by year
PubTator Score 67.49
PubTator score by year
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Related Publications
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PMID
Year
Title