Protein Summary
Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]
- ENST00000265361
- ENSP00000265361
- ENSG00000075223
- ENST00000419255
- ENSP00000411193
- SEMAE
- SemE
- SEMAE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.97 | ||
PubMedID | 0.94 | ||
trait | 0.93 | ||
gene perturbation | 0.89 | ||
transcription factor perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 117.52 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 242 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 117.52 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 242 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (117)
SCGB2A2
Novelty: 0.01594053
p_int: 0.999999118
p_ni: 8.82e-7
Score: 0.173
Data Source: BioPlex,STRINGDB
SEMA3F
Novelty: 0.00676786
p_int: 0.999992792
p_ni: 0.00000174
p_wrong: 0.000005468
Data Source: BioPlex
SDC2
Novelty: 0.00597758
p_int: 0.999442369
p_ni: 0.000235785
p_wrong: 0.000321846
Score: 0.219
Data Source: BioPlex,STRINGDB
TTC38
Novelty: 1.14680208
p_int: 0.999266451
p_ni: 0.000222949
p_wrong: 0.000510599
Data Source: BioPlex
EDDM3B
Novelty: 0.12874735
p_int: 0.995881178
p_ni: 0.003954915
p_wrong: 0.000163907
Data Source: BioPlex
CCL3L1
Novelty: 0.01124082
p_int: 0.995399459
p_ni: 0.004589865
p_wrong: 0.000010675
Data Source: BioPlex
VNN1
Family: Enzyme
Novelty: 0.0144646
p_int: 0.993045533
p_ni: 0.006331311
p_wrong: 0.000623156
Data Source: BioPlex
INS
Novelty: 0.00000499
p_int: 0.991541059
p_ni: 0.008273882
p_wrong: 0.000185059
Score: 0.212
Data Source: BioPlex,STRINGDB
RPL36AL
Novelty: 0.09336423
p_int: 0.969739036
p_ni: 0.030260806
p_wrong: 1.58e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (2)
KEGG (1)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Axon guidance | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (3)
Components (3)
Processes (19)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 5 | 6 | 6 | 98.4 | |||||
mean reticulocyte volume | 1 | 3 | 3 | 93.6 | |||||
platelet count | 3 | 3 | 2 | 4.2 | 92.5 | ||||
high density lipoprotein cholesterol measurement | 3 | 3 | 3 | 89.2 | |||||
mean corpuscular volume | 1 | 2 | 2 | 83.4 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
red blood cell distribution width | 6 | 98.4 | |||||
mean reticulocyte volume | 3 | 93.6 | |||||
platelet count | 2 | 4.2 | 92.5 | ||||
high density lipoprotein cholesterol measurement | 3 | 89.2 | |||||
mean corpuscular volume | 2 | 83.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | semaphorin 3C | VGNC:8749 | 472427 | |||||
Macaque | semaphorin 3C | 708633 | ||||||
Mouse | MGI:107557 | 20348 | ||||||
Rat | RGD:1309343 | 296787 | ||||||
Dog | semaphorin 3C | VGNC:45989 | 475930 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | semaphorin 3C | |||||
Macaque | semaphorin 3C | |||||
Mouse | ||||||
Rat | ||||||
Dog | semaphorin 3C | |||||
Publication Statistics
PubMed Score 117.52
PubMed score by year
PubTator Score 45.68
PubTator score by year
Related Publications
Text Mined References (43)
GeneRif Annotations (21)
Items per page:
0 of 0
PMID | Year | Title |
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