Tbio SEMA3C Semaphorin-3C

Protein Summary

Description

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q99985
• B4DRL8

Gene Name

• SEMA3C

Ensembl ID

• ENST00000265361
• ENSP00000265361
• ENSG00000075223
• ENST00000419255
• ENSP00000411193

Symbol

• SEMAE
• SemE
• SEMAE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
PubMedID	0.94
trait	0.93
gene perturbation	0.89
transcription factor perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Semaphorin-3c

DTO Classes

Protein / Signaling / Membrane-bound Signaling Molecule / Semaphorin-3c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.52   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 242   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.52   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (117)

Explore Interacting Targets

1 – 10 of 117

• See Interactions on String-DB

SEMA3D

Tbio

Novelty:  0.00821843

p_int:  0.999999711

p_ni:  7.1e-8

p_wrong:  2.18e-7

Data Source:  BioPlex

SCGB2A2

Tbio

Novelty:  0.01594053

p_int:  0.999999118

p_ni:  8.82e-7

Score:  0.173

Data Source:  BioPlex,STRINGDB

SEMA3F

Tbio

Novelty:  0.00676786

p_int:  0.999992792

p_ni:  0.00000174

p_wrong:  0.000005468

Data Source:  BioPlex

SDC2

Tbio

Novelty:  0.00597758

p_int:  0.999442369

p_ni:  0.000235785

p_wrong:  0.000321846

Score:  0.219

Data Source:  BioPlex,STRINGDB

TTC38

Tdark

Novelty:  1.14680208

p_int:  0.999266451

p_ni:  0.000222949

p_wrong:  0.000510599

Data Source:  BioPlex

EDDM3B

Tdark

Novelty:  0.12874735

p_int:  0.995881178

p_ni:  0.003954915

p_wrong:  0.000163907

Data Source:  BioPlex

CCL3L1

Tbio

Novelty:  0.01124082

p_int:  0.995399459

p_ni:  0.004589865

p_wrong:  0.000010675

Data Source:  BioPlex

VNN1

Tchem

Family:  Enzyme

Novelty:  0.0144646

p_int:  0.993045533

p_ni:  0.006331311

p_wrong:  0.000623156

Data Source:  BioPlex

INS

Tbio

Novelty:  0.00000499

p_int:  0.991541059

p_ni:  0.008273882

p_wrong:  0.000185059

Score:  0.212

Data Source:  BioPlex,STRINGDB

RPL36AL

Tbio

Novelty:  0.09336423

p_int:  0.969739036

p_ni:  0.030260806

p_wrong:  1.58e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

KEGG (1)

PathwayCommons (1)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Axon guidance	180 targets	path:hsa04360

Name	Explore in Pharos	Explore in Source
Axon guidance	180 targets	path:hsa04360

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (25)

Functions (3)

Components (3)

Processes (19)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
chemorepellent activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
neuropilin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
semaphorin receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	5	6	6		98.4
mean reticulocyte volume	EFO_0010701	1	3	3		93.6
platelet count	EFO_0004309	3	3	2	4.2	92.5
high density lipoprotein cholesterol measurement	EFO_0004612	3	3	3		89.2
mean corpuscular volume	EFO_0004526	1	2	2		83.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	6		98.4
mean reticulocyte volume	EFO_0010701	3		93.6
platelet count	EFO_0004309	2	4.2	92.5
high density lipoprotein cholesterol measurement	EFO_0004612	3		89.2
mean corpuscular volume	EFO_0004526	2		83.4

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Neurogenesis
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
erythrocyte count
hemoglobin measurement
high density lipoprotein cholesterol measurement
hip circumference
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean reticulocyte volume
platelet count

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
embryo phenotype
mortality/aging
pigmentation phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	semaphorin 3C	VGNC:8749	472427
Macaque	semaphorin 3C		708633
Mouse	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	MGI:107557	20348
Rat	semaphorin 3C	RGD:1309343	296787
Dog	semaphorin 3C	VGNC:45989	475930

Species	Name	OMA	EggNOG	Inparanoid
Chimp	semaphorin 3C
Macaque	semaphorin 3C
Mouse	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Rat	semaphorin 3C
Dog	semaphorin 3C

Publication Statistics

PubMed Score 117.52

PubMed score by year

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PubTator Score 45.68

PubTator score by year

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Related Publications

Text Mined References (43)

GeneRif Annotations (21)

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10

0 of 0

PMID	Year	Title