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Tbio
SEMA3C
Semaphorin-3C

Protein Summary
Description
Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265361
  • ENSP00000265361
  • ENSG00000075223
  • ENST00000419255
  • ENSP00000411193

Symbol
  • SEMAE
  • SemE
  • SEMAE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
PubMedID
0.94
trait
0.93
gene perturbation
0.89
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.52   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.52   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
SEMA3D
Tbio
Novelty:  0.00821843
p_int:  0.999999711
p_ni:  7.1e-8
p_wrong:  2.18e-7
Data Source:  BioPlex
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.999999118
p_ni:  8.82e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
SEMA3F
Tbio
Novelty:  0.00676786
p_int:  0.999992792
p_ni:  0.00000174
p_wrong:  0.000005468
Data Source:  BioPlex
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.999442369
p_ni:  0.000235785
p_wrong:  0.000321846
Score:  0.219
Data Source:  BioPlex,STRINGDB
TTC38
Tdark
Novelty:  1.14680208
p_int:  0.999266451
p_ni:  0.000222949
p_wrong:  0.000510599
Data Source:  BioPlex
EDDM3B
Tdark
Novelty:  0.12874735
p_int:  0.995881178
p_ni:  0.003954915
p_wrong:  0.000163907
Data Source:  BioPlex
CCL3L1
Tbio
Novelty:  0.01124082
p_int:  0.995399459
p_ni:  0.004589865
p_wrong:  0.000010675
Data Source:  BioPlex
VNN1
Tchem
Family:  Enzyme
Novelty:  0.0144646
p_int:  0.993045533
p_ni:  0.006331311
p_wrong:  0.000623156
Data Source:  BioPlex
INS
Tbio
Novelty:  0.00000499
p_int:  0.991541059
p_ni:  0.008273882
p_wrong:  0.000185059
Score:  0.212
Data Source:  BioPlex,STRINGDB
RPL36AL
Tbio
Novelty:  0.09336423
p_int:  0.969739036
p_ni:  0.030260806
p_wrong:  1.58e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
6
6
98.4
mean reticulocyte volume
1
3
3
93.6
platelet count
3
3
2
4.2
92.5
high density lipoprotein cholesterol measurement
3
3
3
89.2
mean corpuscular volume
1
2
2
83.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
98.4
mean reticulocyte volume
3
93.6
platelet count
2
4.2
92.5
high density lipoprotein cholesterol measurement
3
89.2
mean corpuscular volume
2
83.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
semaphorin 3C
VGNC:8749
472427
Macaque
semaphorin 3C
708633
Mouse
MGI:107557
20348
Rat
RGD:1309343
296787
Dog
semaphorin 3C
VGNC:45989
475930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
semaphorin 3C
Macaque
semaphorin 3C
Mouse
Rat
Dog
semaphorin 3C
Publication Statistics
PubMed Score 117.52
PubMed score by year
PubTator Score 45.68
PubTator score by year
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Related Publications
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PMID
Year
Title