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Tchem
SELL
L-selectin

Protein Summary
Description
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641). This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236147
  • ENSP00000236147
  • ENSG00000188404

Symbol
  • LNHR
  • LYAM1
  • TQ1
  • LAM1
  • LEU8
  • LNHR
  • LSEL
  • CD62L
  • LYAM1
  • PLNHR
  • LECAM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
biological term
0.95
gene perturbation
0.79
disease
0.76
chemical
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3241.3   (req: < 5)
Gene RIFs: 160   (req: <= 3)
Antibodies: 1371   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3241.3   (req: >= 5)
Gene RIFs: 160   (req: > 3)
Antibodies: 1371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (383)
SELPLG
Tbio
Novelty:  0.0016359
Score:  0.996
Data Source:  Reactome,STRINGDB
MADCAM1
Tbio
Novelty:  0.00325843
Score:  0.962
Data Source:  Reactome,STRINGDB
CD34
Tbio
Novelty:  0.00005468
Score:  0.954
Data Source:  Reactome,STRINGDB
CD44
Tbio
Novelty:  0.00011321
Score:  0.942
Data Source:  STRINGDB
PTPRC
Tchem
Family:  Enzyme
Novelty:  0.00012027
Score:  0.912
Data Source:  STRINGDB
CCR7
Tchem
Family:  GPCR
Novelty:  0.00084453
Score:  0.905
Data Source:  STRINGDB
CD69
Tchem
Novelty:  0.00056432
Score:  0.905
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.89
Data Source:  STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
Score:  0.856
Data Source:  STRINGDB
IL7R
Tbio
Novelty:  0.00107223
Score:  0.854
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cell surface interactions at the vascular wall
Hemostasis
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adhesion molecule measurement
1
2
0
14.9
98.1
blood protein measurement
7
10
13
96.5
e-selectin measurement
2
2
2
96.5
leukocyte count
6
7
9
93.4
L-Selectin measurement
2
1
1
97.6
85.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adhesion molecule measurement
0
14.9
98.1
blood protein measurement
13
96.5
e-selectin measurement
2
96.5
leukocyte count
9
93.4
L-Selectin measurement
1
97.6
85.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
selectin L
VGNC:10991
450191
Macaque
selectin L
701419
Mouse
MGI:98279
20343
Rat
RGD:3655
29259
Dog
selectin L
480080
Species
Name
OMA
EggNOG
Inparanoid
Chimp
selectin L
Macaque
selectin L
Mouse
Rat
Dog
selectin L
Publication Statistics
PubMed Score 3241.30
PubMed score by year
PubTator Score 1503.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title