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Tbio
SELENOP
Selenoprotein P

Protein Summary
Description
Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis. This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000506577
  • ENSP00000425915
  • ENSG00000250722
  • ENST00000511224
  • ENSP00000427671
  • ENST00000514985
  • ENSP00000420939

Symbol
  • SELP
  • SEPP1
  • SeP
  • SELP
  • SEPP
  • SEPP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 737.78   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 737.78   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
CLEC3B
Tbio
Novelty:  0.0037534
Score:  0.933
Data Source:  STRINGDB
ITIH3
Tbio
Novelty:  0.04201144
Score:  0.92
Data Source:  STRINGDB
ITIH4
Tbio
Novelty:  0.00032471
Score:  0.917
Data Source:  STRINGDB
ECM1
Tbio
Novelty:  0.00518679
Score:  0.911
Data Source:  STRINGDB
RARRES2
Tbio
Novelty:  0.0029178
Score:  0.908
Data Source:  STRINGDB
TIMP3
Tbio
Family:  Enzyme
Novelty:  0.00134742
Score:  0.906
Data Source:  STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
Score:  0.906
Data Source:  STRINGDB
APOH
Tbio
Novelty:  0.00049117
Score:  0.904
Data Source:  STRINGDB
SERPINA4
Tbio
Novelty:  0.00483207
Score:  0.904
Data Source:  STRINGDB
FAM3C
Tbio
Novelty:  0.04598347
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
2
2
86.3
IGF-1 measurement
1
1
1
74.1
body weight
2
2
2
69.1
BMI-adjusted hip circumference
1
1
1
48.8
serum urea measurement
1
2
2
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
86.3
IGF-1 measurement
1
74.1
body weight
2
69.1
BMI-adjusted hip circumference
1
48.8
serum urea measurement
2
45.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 737.78
PubMed score by year
PubTator Score 301.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title