You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
SELENOO
Selenoprotein O

Protein Summary
Description
May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein. This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380903
  • ENSP00000370288
  • ENSG00000073169

Symbol
  • SELO
  • SELO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.68   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.68   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.999994591
p_ni:  0.000005399
p_wrong:  1e-8
Data Source:  BioPlex
FAM221B
Tdark
Novelty:  71
p_int:  0.999988257
p_ni:  0.000011735
p_wrong:  9e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
IL17RB
Tbio
Novelty:  0.01540031
p_int:  0.999959617
p_ni:  0.000040381
p_wrong:  2e-9
Data Source:  BioPlex
MYCBP
Tbio
Novelty:  0.03202836
p_int:  0.999279532
p_ni:  0.000371453
p_wrong:  0.000349015
Data Source:  BioPlex
ABHD18
Tdark
Novelty:  10.43528841
p_int:  0.999138859
p_ni:  0.000861092
p_wrong:  4.9e-8
Score:  0.519
Data Source:  BioPlex,STRINGDB
MRM1
Tbio
Family:  Enzyme
Novelty:  0.08762499
p_int:  0.998601449
p_ni:  0.001397379
p_wrong:  0.000001172
Data Source:  BioPlex
PGPEP1
Tbio
Family:  Enzyme
Novelty:  0.00933029
p_int:  0.994911332
p_ni:  0.005088654
p_wrong:  1.4e-8
Score:  0.802
Data Source:  BioPlex,STRINGDB
C1QTNF2
Tbio
Novelty:  0.18607978
p_int:  0.994861986
p_ni:  0.005137915
p_wrong:  9.9e-8
Data Source:  BioPlex
SERPINB2
Tbio
Novelty:  0.00204345
p_int:  0.990524694
p_ni:  0.009474129
p_wrong:  0.000001177
Data Source:  BioPlex
ISOC2
Tbio
Family:  Enzyme
Novelty:  0.33841868
p_int:  0.988474824
p_ni:  0.007386804
p_wrong:  0.004138373
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
3
4
97.7
platelet crit
2
3
4
97.7
hematological measurement
1
1
1
80.4
mitochondrial DNA measurement
1
2
2
76.1
eosinophil count
2
1
2
68.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
97.7
platelet crit
4
97.7
hematological measurement
1
80.4
mitochondrial DNA measurement
2
76.1
eosinophil count
2
68.3
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
selenoprotein O
VGNC:14529
458933
Macaque
selenoprotein O
715604
Mouse
MGI:1919007
223776
Dog
selenoprotein O
VGNC:54544
481194
Horse
selenoprotein O
100056150
Species
Name
OMA
EggNOG
Inparanoid
Chimp
selenoprotein O
Macaque
selenoprotein O
Mouse
Dog
selenoprotein O
Horse
selenoprotein O
Publication Statistics
PubMed Score 37.68
PubMed score by year
PubTator Score 14.99
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title