Protein Summary
May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein. This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Dec 2016]
- ENST00000380903
- ENSP00000370288
- ENSG00000073169
- SELO
- SELO
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.68 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.68 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (63)
RGS20
Novelty: 0.04087618
p_int: 0.999994591
p_ni: 0.000005399
p_wrong: 1e-8
Data Source: BioPlex
FAM221B
Novelty: 71
p_int: 0.999988257
p_ni: 0.000011735
p_wrong: 9e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
IL17RB
Novelty: 0.01540031
p_int: 0.999959617
p_ni: 0.000040381
p_wrong: 2e-9
Data Source: BioPlex
MYCBP
Novelty: 0.03202836
p_int: 0.999279532
p_ni: 0.000371453
p_wrong: 0.000349015
Data Source: BioPlex
ABHD18
Novelty: 10.43528841
p_int: 0.999138859
p_ni: 0.000861092
p_wrong: 4.9e-8
Score: 0.519
Data Source: BioPlex,STRINGDB
MRM1
Family: Enzyme
Novelty: 0.08762499
p_int: 0.998601449
p_ni: 0.001397379
p_wrong: 0.000001172
Data Source: BioPlex
PGPEP1
Family: Enzyme
Novelty: 0.00933029
p_int: 0.994911332
p_ni: 0.005088654
p_wrong: 1.4e-8
Score: 0.802
Data Source: BioPlex,STRINGDB
C1QTNF2
Novelty: 0.18607978
p_int: 0.994861986
p_ni: 0.005137915
p_wrong: 9.9e-8
Data Source: BioPlex
SERPINB2
Novelty: 0.00204345
p_int: 0.990524694
p_ni: 0.009474129
p_wrong: 0.000001177
Data Source: BioPlex
ISOC2
Family: Enzyme
Novelty: 0.33841868
p_int: 0.988474824
p_ni: 0.007386804
p_wrong: 0.004138373
Data Source: BioPlex
Nearest Tclin Targets
Pathways (2)
WikiPathways (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
WikiPathways | Selenium Micronutrient Network | ||||
WikiPathways | Selenium Metabolism and Selenoproteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Selenium Micronutrient Network | ||||
Selenium Metabolism and Selenoproteins | ||||
Viral Interactions (0)
Gene Ontology Terms (1)
Components (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
platelet count | 2 | 3 | 4 | 97.7 | |||||
platelet crit | 2 | 3 | 4 | 97.7 | |||||
hematological measurement | 1 | 1 | 1 | 80.4 | |||||
mitochondrial DNA measurement | 1 | 2 | 2 | 76.1 | |||||
eosinophil count | 2 | 1 | 2 | 68.3 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
platelet count | 4 | 97.7 | |||||
platelet crit | 4 | 97.7 | |||||
hematological measurement | 1 | 80.4 | |||||
mitochondrial DNA measurement | 2 | 76.1 | |||||
eosinophil count | 2 | 68.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | selenoprotein O | VGNC:14529 | 458933 | |||||
Macaque | selenoprotein O | 715604 | ||||||
Mouse | MGI:1919007 | 223776 | ||||||
Dog | selenoprotein O | VGNC:54544 | 481194 | |||||
Horse | selenoprotein O | 100056150 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | selenoprotein O | |||||
Macaque | selenoprotein O | |||||
Mouse | ||||||
Dog | selenoprotein O | |||||
Horse | selenoprotein O | |||||
Publication Statistics
PubMed Score 37.68
PubMed score by year
PubTator Score 14.99
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
---|