Tdark SELENOO Selenoprotein O

Protein Summary

Description

May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein. This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• Q9BVL4
• Q2TAL2
• Q5JZ81
• Q8WUI0
• SelO

Gene Name

• SELENOO

Ensembl ID

• ENST00000380903
• ENSP00000370288
• ENSG00000073169

Symbol

• SELO
• SELO

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.68   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.68   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (63)

Explore Interacting Targets

1 – 10 of 63

• See Interactions on String-DB

RGS20

Tbio

Novelty:  0.04087618

p_int:  0.999994591

p_ni:  0.000005399

p_wrong:  1e-8

Data Source:  BioPlex

FAM221B

Tdark

Novelty:  71

p_int:  0.999988257

p_ni:  0.000011735

p_wrong:  9e-9

Score:  0.189

Data Source:  BioPlex,STRINGDB

IL17RB

Tbio

Novelty:  0.01540031

p_int:  0.999959617

p_ni:  0.000040381

p_wrong:  2e-9

Data Source:  BioPlex

MYCBP

Tbio

Novelty:  0.03202836

p_int:  0.999279532

p_ni:  0.000371453

p_wrong:  0.000349015

Data Source:  BioPlex

ABHD18

Tdark

Novelty:  10.43528841

p_int:  0.999138859

p_ni:  0.000861092

p_wrong:  4.9e-8

Score:  0.519

Data Source:  BioPlex,STRINGDB

MRM1

Tbio

Family:  Enzyme

Novelty:  0.08762499

p_int:  0.998601449

p_ni:  0.001397379

p_wrong:  0.000001172

Data Source:  BioPlex

PGPEP1

Tbio

Family:  Enzyme

Novelty:  0.00933029

p_int:  0.994911332

p_ni:  0.005088654

p_wrong:  1.4e-8

Score:  0.802

Data Source:  BioPlex,STRINGDB

C1QTNF2

Tbio

Novelty:  0.18607978

p_int:  0.994861986

p_ni:  0.005137915

p_wrong:  9.9e-8

Data Source:  BioPlex

SERPINB2

Tbio

Novelty:  0.00204345

p_int:  0.990524694

p_ni:  0.009474129

p_wrong:  0.000001177

Data Source:  BioPlex

ISOC2

Tbio

Family:  Enzyme

Novelty:  0.33841868

p_int:  0.988474824

p_ni:  0.007386804

p_wrong:  0.004138373

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

WikiPathways (2)

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5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Selenium Micronutrient Network	195 targets	WP15_r105808
WikiPathways	Selenium Metabolism and Selenoproteins	228 targets	WP28_r106208

Name	Explore in Pharos	Explore in Source
Selenium Micronutrient Network	195 targets	WP15_r105808
Selenium Metabolism and Selenoproteins	228 targets	WP28_r106208

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Components (1)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
mitochondrion	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (22)

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1 – 5 of 22

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	2	3	4		97.7
platelet crit	EFO_0007985	2	3	4		97.7
hematological measurement	EFO_0004503	1	1	1		80.4
mitochondrial DNA measurement	EFO_0006312	1	2	2		76.1
eosinophil count	EFO_0004842	2	1	2		68.3

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5

1 – 5 of 22

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	4		97.7
platelet crit	EFO_0007985	4		97.7
hematological measurement	EFO_0004503	1		80.4
mitochondrial DNA measurement	EFO_0006312	2		76.1
eosinophil count	EFO_0004842	2		68.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Mitochondrion
Phosphoprotein
Polymorphism
Reference proteome
Selenocysteine

GWAS Trait Find Similar Targets

No Header	No Header
bipolar disorder
body height
cutaneous melanoma
eosinophil count
eosinophil percentage of leukocytes
hair color
hematological measurement
intelligence
liver fibrosis measurement
lymphocyte count

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	selenoprotein O	VGNC:14529	458933
Macaque	selenoprotein O		715604
Mouse	selenoprotein O	MGI:1919007	223776
Dog	selenoprotein O	VGNC:54544	481194
Horse	selenoprotein O		100056150

Species	Name	OMA	EggNOG	Inparanoid
Chimp	selenoprotein O
Macaque	selenoprotein O
Mouse	selenoprotein O
Dog	selenoprotein O
Horse	selenoprotein O

Publication Statistics

PubMed Score 37.68

PubMed score by year

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PubTator Score 14.99

PubTator score by year

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Related Publications

Text Mined References (10)

GeneRif Annotations (2)

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PMID	Year	Title