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Tbio
SELENOH
Selenoprotein H

Protein Summary
Description
May be involved in a redox-related process. This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388857
  • ENSP00000373509
  • ENSG00000211450
  • ENST00000534355
  • ENSP00000434511

Symbol
  • C11orf31
  • SELH
  • SELH
  • C11orf31
  • C17orf10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.59   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.59   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.999999758
p_ni:  2.33e-7
p_wrong:  9e-9
Score:  0.16
Data Source:  BioPlex,STRINGDB
GHITM
Tbio
Novelty:  0.00360652
p_int:  0.998827349
p_ni:  0.001172639
p_wrong:  1.3e-8
Score:  0.168
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.980792508
p_ni:  0.019148598
p_wrong:  0.000058894
Data Source:  BioPlex
SELENOT
Tbio
Novelty:  0.02480242
Score:  0.84
Data Source:  STRINGDB
SELENOW
Tbio
Novelty:  0.00967095
Score:  0.838
Data Source:  STRINGDB
SELENOO
Tdark
Novelty:  0.02959704
Score:  0.821
Data Source:  STRINGDB
SELENOK
Tbio
Novelty:  0.02182816
Score:  0.817
Data Source:  STRINGDB
MSRB1
Tbio
Family:  Enzyme
Novelty:  0.01677161
Score:  0.792
Data Source:  STRINGDB
SELENOF
Tbio
Novelty:  0.01883734
Score:  0.792
Data Source:  STRINGDB
SELENON
Tbio
Novelty:  0.01018
Score:  0.789
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (35)
Find Similar Targets
Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Selenium Micronutrient Network
WikiPathways
Selenium Micronutrient Network
WikiPathways
Selenium Micronutrient Network
WikiPathways
Selenium Micronutrient Network
WikiPathways
Allograft Rejection
Name
Explore in Pharos
Explore in Source
Selenium Micronutrient Network
Selenium Micronutrient Network
Selenium Micronutrient Network
Selenium Micronutrient Network
Allograft Rejection
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
82
neuroticism measurement
5
4
3
6.5
76.7
mean corpuscular hemoglobin concentration
1
1
1
75.2
wellbeing measurement
3
3
3
73.2
self reported educational attainment
1
1
1
69.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
82
neuroticism measurement
3
6.5
76.7
mean corpuscular hemoglobin concentration
1
75.2
wellbeing measurement
3
73.2
self reported educational attainment
1
69.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
selenoprotein H
704535
Mouse
MGI:1919907
72657
Horse
selenoprotein H [Source:HGNC Symbol;Acc:HGNC:18251]
Zebrafish
ZDB-GENE-030411-2
347743
Species
Name
OMA
EggNOG
Inparanoid
Macaque
selenoprotein H
Mouse
Horse
selenoprotein H [Source:HGNC Symbol;Acc:HGNC:18251]
Zebrafish
Publication Statistics
PubMed Score 44.59
PubMed score by year
PubTator Score 13.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title