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Tbio
SELENBP1
Methanethiol oxidase

Protein Summary
Description
Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity). This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368868
  • ENSP00000357861
  • ENSG00000143416
  • ENST00000426705
  • ENSP00000397261
  • ENST00000447402
  • ENSP00000413960

Symbol
  • SBP
  • MTO
  • LPSB
  • SP56
  • hSBP
  • EHMTO
  • SBP56
  • HEL-S-134P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
gene perturbation
0.96
disease perturbation
0.9
interacting protein
0.84
kinase perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.41   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.41   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
MMACHC
Tbio
Novelty:  0.00896291
p_int:  0.99998484
p_ni:  7e-9
p_wrong:  0.000015153
Score:  0.345
Data Source:  BioPlex,STRINGDB
OFCC1
Tdark
Novelty:  0.0424264
p_int:  0.999963252
p_ni:  0.000036748
Score:  0.189
Data Source:  BioPlex,STRINGDB
SGO2
Tbio
Novelty:  0.05544423
p_int:  0.999556185
p_ni:  0.000443815
Data Source:  BioPlex
RAB11B
Tbio
Family:  Enzyme
Novelty:  0.00557558
p_int:  0.999275819
p_ni:  0.000724181
Data Source:  BioPlex
GDF5
Tbio
Novelty:  0.00218118
p_int:  0.998737884
p_ni:  0.00126211
p_wrong:  6e-9
Data Source:  BioPlex
DOLPP1
Tdark
Family:  Enzyme
Novelty:  0.40497097
p_int:  0.998299303
p_ni:  0.001696575
p_wrong:  0.000004122
Score:  0.175
Data Source:  BioPlex,STRINGDB
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.998006495
p_ni:  0.001993505
Data Source:  BioPlex
NSMAF
Tbio
Novelty:  0.08595515
p_int:  0.996483994
p_ni:  0.003516006
Data Source:  BioPlex
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.99550459
p_ni:  0.004495409
p_wrong:  1e-9
Data Source:  BioPlex
CAMKMT
Tbio
Family:  Enzyme
Novelty:  0.00382649
p_int:  0.992285477
p_ni:  0.000001952
p_wrong:  0.007712571
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
66.8
lymphocyte count
1
1
1
29
gut microbiome measurement
1
1
0
5.6
21.5
BMI-adjusted hip circumference
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
66.8
lymphocyte count
1
29
gut microbiome measurement
0
5.6
21.5
BMI-adjusted hip circumference
1
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
selenium binding protein 1
VGNC:1538
469484
Mouse
MGI:104859
20342
Rat
RGD:620571
140927
Dog
selenium binding protein 1
VGNC:45981
475847
Horse
selenium binding protein 1
VGNC:22800
100034054
Species
Name
OMA
EggNOG
Inparanoid
Chimp
selenium binding protein 1
Mouse
Rat
Dog
selenium binding protein 1
Horse
selenium binding protein 1
Publication Statistics
PubMed Score 146.41
PubMed score by year
PubTator Score 3852.67
PubTator score by year
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Related Publications
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PMID
Year
Title