Tbio SEH1L Nucleoporin SEH1

Protein Summary

Description

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the Nup107-160 complex, including this protein, specifically localize to kinetochores in mitosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96EE3
• A8K5B1
• Q8NFU6
• Q96MH3
• Q9C069

Gene Name

• SEH1L

Ensembl ID

• ENST00000262124
• ENSP00000262124
• ENSG00000085415
• ENST00000399892
• ENSP00000382779

Symbol

• SEC13L
• SEH1
• Seh1
• SEH1A
• SEH1B
• SEC13L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	1
interacting protein	0.95
histone modification site profile	0.91
transcription factor binding site profile	0.88
transcription factor perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Nucleoporin Seh1

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Nucleoporin Seh1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.17   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 18   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.17   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0