Protein Summary
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the Nup107-160 complex, including ...more
- ENST00000262124
- ENSP00000262124
- ENSG00000085415
- ENST00000399892
- ENSP00000382779
- SEC13L
- SEH1
- Seh1
- SEH1A
- SEH1B
- SEC13L
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
pathway | 1 | ||
interacting protein | 0.95 | ||
histone modification site profile | 0.91 | ||
transcription factor binding site profile | 0.88 | ||
transcription factor perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.54 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 18 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.54 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 18 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (131)
NELL2
Family: Enzyme
Novelty: 0.03760438
p_int: 0.996105941
p_ni: 0.003894059
Data Source: BioPlex
NUP43
Novelty: 0.11571309
p_int: 0.993266491
p_ni: 0.006733509
Score: 0.995
Data Source: BioPlex,STRINGDB
PDGFD
Novelty: 0.00799996
p_int: 0.964025233
p_ni: 0.035974767
Score: 0.175
Data Source: BioPlex,STRINGDB
PLA2G10
Family: Enzyme
Novelty: 0.00289317
p_int: 0.93752943
p_ni: 0.06247057
Data Source: BioPlex
Nearest Tclin Targets
Pathways (83)
Reactome (81)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Reactome | Amplification of signal from the kinetochores | ||||
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Amplification of signal from the kinetochores | ||||
Antiviral mechanism by IFN-stimulated genes | ||||
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (2)
Components (6)
Processes (12)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
eosinophil count | 2 | 2 | 2 | 72.8 | |||||
hematocrit | 2 | 1 | 2 | 71.2 | |||||
2 | 1 | 2 | 1.1 | 69.4 | |||||
hemoglobin measurement | 1 | 1 | 1 | 65.3 | |||||
lymphocyte count | 2 | 2 | 2 | 60.1 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
eosinophil count | 2 | 72.8 | |||||
hematocrit | 2 | 71.2 | |||||
2 | 1.1 | 69.4 | |||||
hemoglobin measurement | 1 | 65.3 | |||||
lymphocyte count | 2 | 60.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | SEH1 like nucleoporin | VGNC:5203 | 100613956 | |||||
Mouse | MGI:1919374 | 72124 | ||||||
Horse | SEH1 like nucleoporin | VGNC:50969 | 100630847 | |||||
Cow | SEH1 like nucleoporin | VGNC:34420 | 506509 | |||||
Opossum | SEH1 like nucleoporin | 103099906 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | SEH1 like nucleoporin | |||||
Mouse | ||||||
Horse | SEH1 like nucleoporin | |||||
Cow | SEH1 like nucleoporin | |||||
Opossum | SEH1 like nucleoporin | |||||
Publication Statistics
PubMed Score 24.54
PubMed score by year
PubTator Score 3.92
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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