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Tbio
SEC24D
Protein transport protein Sec24D

Protein Summary
Description
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:20427317, PubMed:18843296). Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280551
  • ENSP00000280551
  • ENSG00000150961

Symbol
  • KIAA0755
  • CLCRP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
protein domain
0.92
cellular component
0.79
histone modification site profile
0.75
pathway
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.74   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.74   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (283)
SEC23B
Tbio
Novelty:  0.02307622
p_int:  0.999999442
p_ni:  5.58e-7
Score:  0.989
Data Source:  BioPlex,STRINGDB
PLEKHO1
Tbio
Novelty:  0.01658553
p_int:  0.999561982
p_ni:  0.000437993
p_wrong:  2.5e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
SLC13A2
Tbio
Family:  Transporter
Novelty:  0.01020451
p_int:  0.987202172
p_ni:  0.012352984
p_wrong:  0.000444843
Score:  0.232
Data Source:  BioPlex,STRINGDB
PLPPR2
Tdark
Family:  Enzyme
Novelty:  1.03318406
p_int:  0.971423947
p_ni:  0.028236365
p_wrong:  0.000339688
Score:  0.218
Data Source:  BioPlex,STRINGDB
AMTN
Tbio
Novelty:  0.02514528
p_int:  0.883337062
p_ni:  0.116113738
p_wrong:  0.0005492
Score:  0.221
Data Source:  BioPlex,STRINGDB
TMA16
Tdark
Novelty:  0.89810617
p_int:  0.883337062
p_ni:  0.116113738
p_wrong:  0.0005492
Score:  0.189
Data Source:  BioPlex,STRINGDB
IL17F
Tclin
Novelty:  0.00223549
p_int:  0.882226969
p_ni:  0.117773031
Data Source:  BioPlex
SEC23A
Tbio
Novelty:  0.0384262
Score:  0.999
Data Source:  Reactome,STRINGDB
SEC24A
Tbio
Novelty:  0.07724534
Score:  0.998
Data Source:  Reactome,STRINGDB
SEC24C
Tbio
Novelty:  0.05842956
Score:  0.994
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (45)
Adaptive Immune System (R-HSA-1280218)

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Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
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Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
49.3
corneal resistance factor
1
1
1
49.2
aortic vascular smooth muscle cell calcification measurement
1
1
1
38.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
49.3
corneal resistance factor
1
49.2
aortic vascular smooth muscle cell calcification measurement
1
38.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SEC24 homolog D, COPII coat complex component
707521
Mouse
MGI:1916858
69608
Rat
RGD:1311720
310843
Dog
SEC24 homolog D, COPII coat complex component
VGNC:45975
478523
Horse
SEC24 homolog D, COPII coat complex component
VGNC:22795
100064058
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SEC24 homolog D, COPII coat complex component
Mouse
Rat
Dog
SEC24 homolog D, COPII coat complex component
Horse
SEC24 homolog D, COPII coat complex component
Publication Statistics
PubMed Score 21.74
PubMed score by year
PubTator Score 13.92
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title